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Hand Controlled Manipulation of Single Molecules via a Scanning Probe Microscope with a 3D Virtual Reality Interface

Hand Controlled Manipulation of Single Molecules via a Scanning Probe Microscope with a 3D Virtual Reality Interface

Published on: October 2, 2016

Micro-manipulation system with a two-fingered micro-hand and its potential application in bioscience.

Kenji Inoue¹, Tamio Tanikawa, Tatsuo Arai

¹Department of Systems Innovation, Graduate School of Engineering Science, Osaka University, Osaka, Japan. inoue@sys.es.osaka-u.ac.jp

Journal of Biotechnology

|September 25, 2007

Summary

This study introduces a novel micro-manipulation system with a 6-DOF micro-hand for precise handling of micro-objects like cells. Applications include efficient cytoplasm extraction and mechanical property measurement of biological cells.

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Area of Science:

Biotechnology
Micro-robotics
Cell Biology

Background:

Precise manipulation of micro-objects, such as biological cells, is crucial for various bioscience applications.
Existing micro-manipulation systems often lack the dexterity and versatility required for complex tasks.

Purpose of the Study:

To develop and demonstrate a novel micro-manipulation system with a 6-degrees of freedom (DOF) two-fingered micro-hand.
To showcase the system's utility in two key bioscience applications: cytoplasm extraction and mechanical property measurement of living cells.

Main Methods:

Development of a micro-manipulation system integrating a 6-DOF micro-hand, an auto-focusing optical microscope, and user interfaces (joystick/keyboard).
Application 1: Cytoplasm extraction using two micro-hands to hold, puncture, and squeeze a cell.
Application 2: Mechanical property measurement using the micro-hand and an Atomic Force Microscope (AFM) cantilever to generate force-deformation curves.

Main Results:

The developed micro-hand successfully demonstrated grasping, moving, rotating, and releasing micro-objects.
Successful extraction of cytoplasm from a cell was achieved through controlled manipulation.
Accurate force-deformation curves for living cells were obtained, enabling mechanical property analysis.

Conclusions:

The developed micro-manipulation system offers high dexterity and precise control for micro-object handling.
The system is a valuable tool for advanced bioscience research, particularly in cell manipulation and mechanical characterization.
This technology has the potential to significantly advance fields requiring intricate manipulation of biological samples.