Related Experiment Video

Updated: Jul 11, 2026

High-throughput Assay to Phenotype Salmonella enterica Typhimurium Association, Invasion, and Replication in Macrophages
11:10

High-throughput Assay to Phenotype Salmonella enterica Typhimurium Association, Invasion, and Replication in Macrophages

Published on: August 11, 2014

Epidemiologic attributes of invasive non-typhoidal Salmonella infections in Michigan, 1995--2001

M Mokhtar Arshad1, Melinda J Wilkins, Frances P Downes

  • 1Department of Large Animal Clinical Sciences, Michigan State University, East Lansing, Michigan, USA.

International Journal of Infectious Diseases : IJID : Official Publication of the International Society for Infectious Diseases
|September 25, 2007
PubMed
Abstract

Insights

Infants under one year old face a significantly higher risk of invasive Salmonella infections. This study highlights the importance of considering invasive salmonellosis in young children with Salmonella-positive stool cultures.

Area of Science:

  • Public Health
  • Infectious Diseases
  • Epidemiology

Background:

  • Invasive salmonellosis poses a significant public health concern.
  • Understanding the incidence and risk factors is crucial for effective prevention and treatment.

Purpose of the Study:

  • To determine the incidence of invasive salmonellosis in Michigan.
  • To identify common Salmonella serotypes causing invasive disease.
  • To analyze demographic factors associated with invasive salmonellosis.

Main Methods:

  • A cross-sectional study analyzed laboratory-confirmed Salmonella cases reported in Michigan from 1995 to 2001.
  • Average annual incidences were calculated.
  • Poisson regression modeling assessed the association between demographics and invasive disease.

Main Results:

  • The incidence of invasive salmonellosis was 0.5 per 100,000 people.
  • Infants under one year old had a significantly higher risk (RR 8.98) compared to adults aged 40-49.
  • Salmonella serotype Heidelberg showed the highest blood invasiveness ratio (15.79/100).

Conclusions:

  • Young children, particularly those under one year, are at elevated risk for invasive Salmonella infections.
  • Invasive salmonellosis should be considered in the differential diagnosis for young children with Salmonella in stool cultures.
  • While no significant differences were found by race or sex, age remains a critical risk factor.

More Related Videos

Characterizing Salmonella Typhimurium-induced Septic Peritonitis in Mice14:10

Characterizing Salmonella Typhimurium-induced Septic Peritonitis in Mice

Published on: July 29, 2022

Related Concept Videos

Investigation of Disease Outbreaks01:23

Investigation of Disease Outbreaks

Multistate foodborne outbreaks pose significant public health risks and require meticulous investigation to identify sources and implement control measures. The Centers for Disease Control and Prevention (CDC) utilizes a dynamic seven-step process for these investigations, integrating data from laboratories, interviews, and environmental assessments to protect public health.Outbreak Detection: The detection of multistate outbreaks typically begins with PulseNet, the CDC's national laboratory...
Reservoir of Infection01:30

Reservoir of Infection

Infectious diseases arise from intricate interactions between pathogens and their reservoirs. A reservoir of infection refers to the natural habitat where a pathogen lives, grows, and multiplies, serving as a continual source of infection. Reservoirs are broadly classified as either living or nonliving, and each plays a unique role in disease transmission, significantly influencing public health interventions and control strategies.Humans act as reservoirs for a wide array of pathogens,...
Bacterial Gastroenteritis01:18

Bacterial Gastroenteritis

Bacterial gastroenteritis, characterized by diarrhea, abdominal cramps, and vomiting, is often caused by ingestion of contaminated food or water and is frequently associated with pathogenic Escherichia coli strains. These microbes exploit two principal mechanisms to inflict disease.Shiga toxin–producing E. coli, also referred to as STEC—notably O157:H7—release Shiga toxins that target ribosomes, blocking protein synthesis. The B subunit of the toxin binds the host glycolipid receptor...
Sources of Food Contamination01:29

Sources of Food Contamination

Contamination of food by microbial agents and natural toxins poses significant risks to public health. These hazards can be introduced at various points across the food supply chain, ranging from environmental sources to processing and storage stages. Understanding these contamination pathways is critical for developing strategies to ensure food safety.Seafood is particularly vulnerable to contamination through both environmental exposure and microbial colonization. Toxins from harmful algal...
Evolution of Microbial Genome01:08

Evolution of Microbial Genome

Microbial genome evolution is a highly dynamic process shaped by continual gene gain and loss across species and strains. This genomic flexibility allows microorganisms to adapt rapidly to environmental pressures and interactions with other organisms. Central to understanding this diversity is the distinction between the core and pan genomes.The core genome comprises the genes shared by all sampled strains of a species, representing essential functions needed for fundamental cellular processes.
Clinical Significance of Antibiotic Resistance01:25

Clinical Significance of Antibiotic Resistance

Methicillin-resistant Staphylococcus aureus (MRSA) presents a critical public health threat, arising from its capacity to resist β-lactam antibiotics due to acquisition of the mecA gene within the staphylococcal cassette chromosome mec (SCCmec). This gene encodes penicillin-binding protein 2a (PBP2a), which impairs binding efficacy of methicillin and other β-lactams. MRSA has evolved into distinct clonal lineages impacting humans and animals alike, reinforcing its significance within the One...