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Updated: Jan 8, 2026
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Assaying Circuit Specific Regulation of Adult Hippocampal Neural Precursor Cells
Published on: July 24, 2019
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DISC1 puts the brakes on neurogenesis
1Departments of Psychiatry and Neuroscience, Columbia University, New York, NY 10032, USA. ad722@columbia.edu
Cell
|September 25, 2007
Summary
Disrupted-in-Schizophrenia 1 (DISC1) gene impacts new neuron development in adult mice. DISC1 shows opposing roles in neurogenesis during development versus adulthood, offering new schizophrenia insights.
Area of Science:
- Neuroscience
- Genetics
- Molecular Biology
Background:
- The Disrupted-in-Schizophrenia 1 (DISC1) gene is a key genetic factor linked to schizophrenia.
- Research investigates DISC1's role in neuronal development and integration within the adult hippocampus.
Discussion:
- DISC1 influences the maturation and integration of newly generated neurons in the adult mouse hippocampus.
- The gene exhibits contrasting effects on neurogenesis during different life stages (development vs. adulthood).
Key Insights:
- Evidence suggests DISC1 is crucial for adult hippocampal neurogenesis.
- DISC1's dual role in neurogenesis highlights its complex involvement in brain function.
Outlook:
- Further research into DISC1's mechanisms could reveal novel therapeutic targets for schizophrenia.
- Understanding DISC1's stage-specific functions is vital for deciphering its contribution to psychiatric disorders.
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