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Diffuse large B-cell lymphoma with a novel translocation involving BCL6
1Department of Pathology, North Shore University Hospital, 300 Community Drive, Manhasset, NY 11030, USA. jabel.iqbal@roswellpark.org
Cancer Genetics and Cytogenetics
|September 25, 2007
Summary
A novel BCL6 gene translocation to chromosome 11 was identified in diffuse large B-cell lymphoma (DLBCL). This finding, involving non-immunoglobulin genes, offers new insights into DLBCL pathogenesis.
Area of Science:
- Hematology
- Oncology
- Genetics
Background:
- Diffuse large B-cell lymphoma (DLBCL) is a common non-Hodgkin lymphoma.
- BCL6 gene translocations are frequent in DLBCL, typically involving its 5' regulatory region.
- These translocations often partner with immunoglobulin or non-immunoglobulin genes.
Observation:
- A case of germinal center type DLBCL was identified.
- This case exhibited a translocation of the BCL6 gene to chromosome 11.
- The translocation involved one or more non-immunoglobulin partner genes.
Findings:
- A novel BCL6 translocation to chromosome 11 with non-immunoglobulin partners was observed.
- This specific translocation in an activated B-cell type DLBCL is, to our knowledge, previously undescribed.
- The translocation occurred in a case with germinal center immunophenotypic features.
Implications:
- This discovery expands the known spectrum of BCL6 translocations in DLBCL.
- Further research is warranted to identify the specific partner gene(s) and their pathophysiological role.
- Understanding this novel translocation may lead to new diagnostic or therapeutic strategies for DLBCL.
