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I/D genetic polymorphism of angiotensin-converting enzyme: pathogenesis evaluation for erectile dysfunction by gene
1Department of Laboratory Medicine, Faculty of Medicine, Chulalongkorn University, Bangkok, Thailand.
Objective:
Angiotensin-converting enzyme (ACE) is the major regulator of mineralocorticoid synthesis and it is in the renin/angiotensin system. Angiotensin-converting enzyme is responsible for several vascular diseases. It also relates to erectile dysfunction. However, in-depth analysis on the effect of genetic I/D polymorphism of ACE has never been performed. The molecular mechanisms for each genotype expression in erectile dysfunction are poorly understood.
Design:
Gene ontology technique.
Setting:
Chulalongkorn University Hospital, Bangkok, Thailand.
Patient(S):
Men with erectile dysfunction.
Interventions:
In the present study, I have used a new gene ontology technique to predict the molecular function and biological process for the II, ID, and DD genotypes of ACE.
Main Outcome Measure(S):
Molecular function and biological process.
Result(S):
According to this gene ontology study, it can be shown that the DD genotype lacks molecular function and biological process.
Conclusion(S):
The lack of carboxypeptidase activity in DD genotype might be the clue for erectile dysfunction pathogenesis.
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