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Updated: Jul 11, 2026

Unraveling Entropic Rate Acceleration Induced by Solvent Dynamics in Membrane Enzymes
Published on: January 16, 2016
Thermodynamics of mechanical transduction of surface confined receptor/ligand reactions
Paolo Bergese1, Giulio Oliviero, Ivano Alessandri
1INSTM and Chemistry for Technologies Laboratory, University of Brescia, via Branze 38, 25123 Brescia, Italy. paolo.bergese@ing.unibs.it
Abstract:
Chemomechanics of surface stress is discussed in terms of interfacial thermodynamics. In the first section the paper shows how to quantitatively describe the chemical equilibrium of a receptor/ligand binding reaction confined at a solid-liquid interface and how the overall work of the reaction splits into chemical and surface work, that appears as a surface pressure. In the second section this thermodynamic model is applied to describe the experimental results of microcantilever bending induced by DNA hybridization occurring onto one of its faces.
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