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Related Concept Videos

Proteomics01:33

Proteomics

A proteome is the entire set of proteins that a cell type produces. We can study proteomes using the knowledge of genomes because genes code for mRNAs, and the mRNAs encode proteins. Although mRNA analysis is a step in the right direction, not all mRNAs are translated into proteins.
Proteomics is the study of proteomes' function. It involves the large-scale systematic study of the proteome to denote the protein complement expressed by a genome. Scientist Mark Wilkins coined the term proteomics...
Peptide Identification Using Tandem Mass Spectrometry01:33

Peptide Identification Using Tandem Mass Spectrometry

Tandem mass spectrometry, also known as MS/MS or MS2, is an analytical technique that employs two mass analyzers. Essentially it is a series of mass spectrometers that helps isolate a particular biomolecule and then helps study its chemical properties.
This technique helps gather information regarding the protein from which the peptide was obtained and to study the peptides’ amino acid sequence. Identifying peptides from a complex mixture is an important component of the growing field of...

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Related Experiment Video

Updated: Jul 11, 2026

Comprehensive Workflow of Mass Spectrometry-based Shotgun Proteomics of Tissue Samples
14:51

Comprehensive Workflow of Mass Spectrometry-based Shotgun Proteomics of Tissue Samples

Published on: November 13, 2021

How will haematologists use proteomics?

Richard D Unwin1, Anthony D Whetton

  • 1Stem Cell and Leukaemia Proteomics Laboratory, Faculty of Medical and Human Sciences, University of Manchester, Christie Hospital, Kinnaird House, Kinnaird Road, Withington, Manchester, UK M20 4QL. runwin@manchester.ac.uk

Blood Reviews
|September 25, 2007
PubMed
Summary

Proteomics offers new ways to find disease biomarkers and understand biological systems, especially in hematology. Novel proteomic methods can detect key protein changes in leukemia and utilize serum for clinical insights.

Related Experiment Videos

Last Updated: Jul 11, 2026

Comprehensive Workflow of Mass Spectrometry-based Shotgun Proteomics of Tissue Samples
14:51

Comprehensive Workflow of Mass Spectrometry-based Shotgun Proteomics of Tissue Samples

Published on: November 13, 2021

Area of Science:

  • Biochemistry
  • Molecular Biology
  • Clinical Diagnostics

Background:

  • Proteomics technologies are crucial for identifying disease biomarkers.
  • Cellular changes in protein expression are often best characterized at the proteome level.
  • Altered translation and degradation rates significantly impact protein expression.

Purpose of the Study:

  • To review proteomic technologies applicable to hematology.
  • To highlight the potential of serum proteomics in clinical settings.
  • To discuss the role of proteomics in understanding leukemia pathology.

Main Methods:

  • Analysis of emerging proteomics technologies.
  • Detection of post-translational protein modifications (e.g., phosphorylation, acetylation).
  • Exploration of serum as a source for proteomic research.

Main Results:

  • Proteomics enables characterization of normal and disease processes.
  • Novel methods can detect critical protein modifications in leukemia.
  • Serum proteomics presents opportunities for hematological research.

Conclusions:

  • Proteomics is a valuable tool for hematology research and clinical applications.
  • Serum proteomics holds significant promise for prognosis and therapy response.
  • Advanced proteomic methods are key to advancing understanding of hematological diseases.