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Quantitative Structure-Activity Relationship, Activity Prediction, and Molecular Dynamics of Non-nucleotide Reverse Transcriptase Inhibitors
Published on: May 9, 2025
Synthesis, anti-HIV and antitubercular activities of nelfinavir diester derivatives
Dharmarajan Sriram1, Perumal Yogeeswari, Murugesan Dinakaran
1Medicinal Chemistry Research Laboratory, Pharmacy Group, Birla Institute of Technology & Science, Pilani, Rajasthan, India. dsiram@bits-pilani.ac.in
Abstract:
Nelfinavir diesters were prepared by reacting nelfinavir with two molar amount of an appropriate substituted aromatic/aliphatic acid in the presence of dicylohexyl carbodiimide as the carboxyl group activator and 4-dimethylamino pyridine as catalyst. The synthesized compounds were evaluated for their inhibitory effects on the replication of HIV-1 (IIIB) in MT-4 cells by MTT assay method and antimycobacterial activity against Mycobacterium tuberculosis H37Rv by agar dilution method. Compound 3f emerged as the most potent anti-HIV agent with EC(50) of 0.043 microM and CC(50) more than >10 microM and was more potent than parent nelfinavir (EC(50) of 0.060 microM) and also showed antimycobacterial activity (MIC 8.49 microM).
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