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Sweet's syndrome in Behçet's disease
Hasna Hassikou1, Fatima Tabache, Mohamed Baaj
1Internal Medicine Department, Moulay Ismail Military Hospital, Meknes, Morocco. hassikouhasna@hotmail.com
Joint Bone Spine
|September 25, 2007
Summary
Sweet's syndrome, a rare skin condition, can occur in patients with Behçet's disease, an inflammatory disorder. This case highlights the overlap in symptoms and suggests Behçet's disease may underlie Sweet's syndrome.
Area of Science:
- Dermatology
- Rheumatology
- Internal Medicine
Background:
- Sweet's syndrome is an acute febrile neutrophilic dermatosis characterized by fever, neutrophilia, and tender, erythematous skin lesions.
- Behçet's disease is a chronic, multisystem inflammatory disorder of unknown etiology, typically presenting with recurrent oral and genital ulcers, skin lesions, and uveitis.
Observation:
- A 47-year-old woman with a history of undiagnosed oral and genital ulcers presented with acute onset of tender, erythematous, vesicle-like papules on her face, neck, palms, and legs.
- The patient also reported polyarthralgia, weight loss, fever, conjunctivitis, and joint tenderness.
- Skin biopsy confirmed Sweet's syndrome, and a positive pathergy test suggested hypersensitivity.
Findings:
- The patient exhibited clinical manifestations overlapping between Sweet's syndrome and Behçet's disease.
- Laboratory findings revealed inflammation and leukocytosis with neutrophilia.
- Treatment with glucocorticoids and colchicine effectively resolved the patient's symptoms.
Implications:
- This case underscores the potential overlap in clinical presentations between Sweet's syndrome and Behçet's disease.
- The findings suggest that Behçet's disease should be considered in the differential diagnosis of patients presenting with Sweet's syndrome.
- Further research is warranted to elucidate the relationship between these two conditions.
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