Related Experiment Video
Updated: Jul 11, 2026

Transient Middle Cerebral Artery Occlusion Model of Neonatal Stroke in P10 Rats
Published on: April 21, 2017
Early cognitive outcome after neonatal stroke
Angela McLinden1, Anne D Baird, Robyn Westmacott
1University of Windsor, Windsor, Ontario, Canada.
Insights
Children with neonatal stroke show significant cognitive impairments in the first two years. Early assessments reveal lower scores on key developmental indices, indicating a need for further research into long-term outcomes.
Area of Science:
- Neuroscience
- Developmental Psychology
- Pediatrics
Background:
- Neonatal stroke, occurring within the first 28 days of life, can impact long-term neurodevelopment.
- Cognitive development in infants is crucial for overall childhood progression.
Purpose of the Study:
- To assess the cognitive development of children diagnosed with nonhemorrhagic neonatal stroke.
- To identify potential differences in cognitive outcomes based on stroke characteristics.
Main Methods:
- Utilized the Bayley Scales of Infant Development for cognitive evaluation.
- Administered assessments at 12 and/or 24 months post-stroke to 27 children.
- Compared participant scores against a normative sample.
Main Results:
- Children with neonatal stroke scored significantly lower on the Bayley Psychomotor Development Index at 12 months.
- At 24 months, significant deficits were observed in both the Bayley Mental and Psychomotor Development Indices.
- No significant differences in outcomes were found based on stroke type or infarct laterality.
Conclusions:
- Neonatal stroke is associated with significant cognitive impairment within the first two years of life.
- Further research is needed to track the long-term cognitive trajectory of these children.
- Understanding the evolving cognitive landscape post-neonatal stroke is critical for intervention planning.
Abstract:
The purpose of this study was to assess the cognitive development of 27 children with nonhemorrhagic neonatal stroke (occurring within the first 28 days of life). The cognitive evaluation consisted of the Bayley Scales of Infant Development, administered at 12 and/or 24 months poststroke. Compared with the normative sample, children with neonatal stroke obtained significantly lower scores on the Bayley Psychomotor Development Index at 12 months poststroke and on the Bayley Mental and Psychomotor Development Indices at 24 months poststroke. Outcome did not differ based on stroke type or laterality of infarct. However, there was a trend toward higher scores on the Bayley Psychomotor Development Index at 24 months in the left hemisphere group compared to the right hemisphere group. Overall, children with neonatal stroke evidenced significant impairment within the first 2 years poststroke. Further research is required to confirm whether cognitive impairments in these children resolve, remain in the low-average range, or increase with development as more complex skills are learned.
Related Concept Videos
Ischemic Stroke l: Introduction
Ischemic Stroke ll: Pathophysiology