Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Ischemic Stroke l: Introduction01:15

Ischemic Stroke l: Introduction

Ischemic stroke is an acute cerebrovascular condition in which blood flow to a brain region is suddenly interrupted, leading to tissue infarction. Neurons depend on continuous oxygen and glucose supply, so even brief reductions in perfusion cause energy failure, ionic imbalance, and irreversible injury. Ischemic strokes are classified into thrombotic and embolic types based on their underlying mechanisms.Thrombotic MechanismsThrombotic stroke develops when a clot forms within a cerebral artery.
Ischemic Stroke ll: Pathophysiology01:15

Ischemic Stroke ll: Pathophysiology

An ischemic stroke occurs when a cerebral blood vessel becomes obstructed, most often by a thrombus or embolus, interrupting the delivery of oxygen and glucose to brain tissue. Because neurons rely on continuous aerobic metabolism, energy failure begins within minutes of reduced perfusion. The region receiving the least blood flow becomes the infarct core, an area of irreversible cellular death. Surrounding this core lies the penumbra, a zone of hypoperfused but still viable tissue that is...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Expert Consensus Approach to Developing Inpatient Common Data Elements for Neonatal Encephalopathy Research.

Neurology·2026
Same author

Language History Collection in Multilingual Clinical Practice: A Qualitative Analysis of Public-Sector Clinical Perspectives.

International journal of language & communication disorders·2026
Same author

Rethinking language outcomes after neonatal stroke.

Developmental medicine and child neurology·2026
Same author

The International Pediatric Stroke Study: Insight into Childhood Stroke from a Developmental Perspective.

The Journal of pediatrics·2025
Same author

Current State of the Global Pediatric Stroke Care-Results From the Global Alliance for Pediatric Stroke Epidemiology and Resources Survey.

Pediatric neurology·2025
Same author

Proceedings of the 15<sup>th</sup> International Newborn Brain Conference: Neonatal Neurocritical Care, seizures, and continuous aEEG and /or EEG monitoring: Fota Island, Cork, Ireland, February 28<sup>th</sup> - March 2<sup>nd</sup> 2024.

Journal of neonatal-perinatal medicine·2025

Related Experiment Video

Updated: Jul 11, 2026

Transient Middle Cerebral Artery Occlusion Model of Neonatal Stroke in P10 Rats
07:56

Transient Middle Cerebral Artery Occlusion Model of Neonatal Stroke in P10 Rats

Published on: April 21, 2017

Early cognitive outcome after neonatal stroke.

Angela McLinden1, Anne D Baird, Robyn Westmacott

  • 1University of Windsor, Windsor, Ontario, Canada.

Journal of Child Neurology
|September 25, 2007
PubMed
Summary

Children with neonatal stroke show significant cognitive impairments in the first two years. Early assessments reveal lower scores on key developmental indices, indicating a need for further research into long-term outcomes.

Related Experiment Videos

Last Updated: Jul 11, 2026

Transient Middle Cerebral Artery Occlusion Model of Neonatal Stroke in P10 Rats
07:56

Transient Middle Cerebral Artery Occlusion Model of Neonatal Stroke in P10 Rats

Published on: April 21, 2017

Area of Science:

  • Neuroscience
  • Developmental Psychology
  • Pediatrics

Background:

  • Neonatal stroke, occurring within the first 28 days of life, can impact long-term neurodevelopment.
  • Cognitive development in infants is crucial for overall childhood progression.

Purpose of the Study:

  • To assess the cognitive development of children diagnosed with nonhemorrhagic neonatal stroke.
  • To identify potential differences in cognitive outcomes based on stroke characteristics.

Main Methods:

  • Utilized the Bayley Scales of Infant Development for cognitive evaluation.
  • Administered assessments at 12 and/or 24 months post-stroke to 27 children.
  • Compared participant scores against a normative sample.

Main Results:

  • Children with neonatal stroke scored significantly lower on the Bayley Psychomotor Development Index at 12 months.
  • At 24 months, significant deficits were observed in both the Bayley Mental and Psychomotor Development Indices.
  • No significant differences in outcomes were found based on stroke type or infarct laterality.

Conclusions:

  • Neonatal stroke is associated with significant cognitive impairment within the first two years of life.
  • Further research is needed to track the long-term cognitive trajectory of these children.
  • Understanding the evolving cognitive landscape post-neonatal stroke is critical for intervention planning.