Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Epikeratophakia for high myopia.

J O Hjortdal1, N Ehlers

  • 1Department of Ophthalmology, Arhus University Hospital, Denmark.

Acta Ophthalmologica
|December 1, 1991
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Osteogenesis imperfecta and the teeth, eyes, and ears-a study of non-skeletal phenotypes in adults.

Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA·2018
Same author

Continuous hypoxic culturing maintains activation of Notch and allows long-term propagation of human embryonic stem cells without spontaneous differentiation.

Cell proliferation·2009
Same author

Evaluation of potential organ culture media for eye banking using a human corneal endothelial cell growth assay.

Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie·2002
Same author

Evaluation of potential organ culture media for eye banking using human donor corneas.

The British journal of ophthalmology·2001
Same author

Treatment of post-keratoplasty astigmatism by topography supported customized laser ablation.

Acta ophthalmologica Scandinavica·2001
Same author

Human lens thioltransferase: cloning, purification, and function.

Investigative ophthalmology & visual science·2001
Same journal

En face localization of retinal telangiectatic capillaries using OCT compared with ICG angiography in chronic vascular macular oedema.

Acta ophthalmologica·2026
Same journal

Usher syndrome-related visual impairment in Finland: A 35-year nationwide register-based study (1985-2019).

Acta ophthalmologica·2026
Same journal

Three years of ocular proton therapy in the Netherlands, clinical results.

Acta ophthalmologica·2026
Same journal

Risk factors for acquisition and severity of Acanthamoeba and Fusarium keratitis in contact lens users-A case-control and clinical-epidemiological study, 2009-2020.

Acta ophthalmologica·2026
Same journal

Distinguish polypoidal choroidal vasculopathy through choroidal alterations: A systematic review, meta-analysis and narrative synthesis.

Acta ophthalmologica·2026
Same journal

Ocular blood flow and retinal oxygen saturation measurements in central retinal artery occlusion.

Acta ophthalmologica·2026
See all related articles

A novel cryo-technique for corneal epi-lens production shows promise for treating high myopia. This method resulted in clear lenses and improved vision in patients undergoing epikeratophakia surgery.

Area of Science:

  • Ophthalmology
  • Biomaterials Science
  • Surgical Techniques

Background:

  • High myopia presents significant visual challenges.
  • Current treatments for high myopia have limitations.
  • Corneal refractive surgery offers potential solutions.

Purpose of the Study:

  • To develop and evaluate a cryo-technique for producing corneal epi-lenses.
  • To assess the safety and efficacy of epikeratophakia using these manufactured epi-lenses for high myopia correction.

Main Methods:

  • A cryo-technique was employed to mold the anterior surface and microtome-cut the posterior surface of corneal tissue for epi-lens production.
  • Epi-lenses were stored in organ culture medium prior to implantation.
  • Epikeratophakia surgery was performed on twelve eyes in ten patients with high myopia (>-7 D).

Related Experiment Videos

Main Results:

  • Complete epithelialization occurred within one week post-surgery in all treated eyes.
  • All implanted epi-lenses remained clear at 3-18 months follow-up.
  • Significant refractive correction was achieved, with an average spherical equivalent change of 9.7 +/- 4.4 D, leading to improved uncorrected visual acuity without significant loss of best-corrected visual acuity.

Conclusions:

  • The developed cryo-technique is effective for producing clear corneal epi-lenses.
  • Epikeratophakia using these cryo-produced epi-lenses is a safe and effective treatment for high myopia.
  • The technique promotes good visual outcomes and maintains corneal health post-surgery.