The correlation between serum progesterone and aqueous dynamics during the menstrual cycle

Exogenously-administered progesterone has been shown to lower intraocular pressure. However, attempts to correlate endogenous progesterone levels and aqueous dynamics have produced inconsistent results. In this study, 20 healthy, non-pregnant women were followed over a 28-day menstrual cycle. Serum progesterone level, intraocular pressure, and aqueous flow rate were measured weekly. We were unable to demonstrate any correlation between progesterone levels and either aqueous flow or intraocular pressure.