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Related Experiment Videos

Does the number or quality of pluripotent bone marrow stem cells decrease with age?

Kevin Garvin1, Connie Feschuk, J Graham Sharp

  • 1Department of Orthopaedic Surgery and Rehabilitation, University of Nebraska Medical Center at Omaha, Omaha, NE 68198-1080, USA. kgarvin@unmc.edu

Clinical Orthopaedics and Related Research
|September 25, 2007
PubMed
Summary
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As aging populations increase joint replacement surgeries, understanding stem cells is key. Research shows total side population stem cells decrease with age, but their quality remains stable, offering potential for enhanced bone remodeling.

Area of Science:

  • Biomedical Engineering
  • Regenerative Medicine
  • Gerontology

Background:

  • Aging populations are driving a significant increase in total joint arthroplasties.
  • Periprosthetic bone remodeling and stem cell function are critical for joint replacement longevity.
  • Current challenges include managing increased surgical demand and reducing revision rates.

Purpose of the Study:

  • To investigate the correlation between age and the quantity/quality of side population stem cells.
  • To determine if side population stem cells can be evaluated in peripheral blood.
  • To explore the potential of manipulating these cells for improved peri-prosthetic bone remodeling.

Main Methods:

  • Flow cytometry analysis of side population stem cells from bone marrow and peripheral blood.

Related Experiment Videos

  • Inclusion of 54 patients undergoing total hip arthroplasty (THA), stratified by age (<60 and >60 years).
  • Assessment of stem cell quantity (total count) and quality (long-term repopulating ability).

    • Main Results:

    • A decrease in the total number of side population stem cells was observed with increasing age.
    • The long-term repopulating ability (quality) of side population stem cells remained constant across age groups.
    • A significant correlation was found between the total count of side population stem cells in bone marrow and peripheral blood.

    Conclusions:

    • Age negatively impacts the quantity of side population stem cells but not their quality.
    • Peripheral blood can serve as a viable source for evaluating side population stem cells.
    • Potential exists for therapeutic manipulation of side population stem cells to enhance peri-prosthetic bone remodeling and reduce revision rates.