Related Experiment Video
Updated: Jul 11, 2026
09:49
A Whole Body Dosimetry Protocol for Peptide-Receptor Radionuclide Therapy (PRRT): 2D Planar Image and Hybrid 2D+3D SPECT/CT Image Methods
Published on: April 24, 2020
Value of sestamibi scans in tertiary hyperparathyroidism
Kelly A Loftus1, Susan Anderson, Anthony L Mulloy
1Department of Medicine, Section of Endocrinology, Diabetes and Metabolism, MCG Thyroid/Parathyroid Center, Medical College of Georgia, Augusta, GA 30912-4060, USA.
The Laryngoscope
|September 25, 2007
Summary
Preoperative technetium Tc-99m sestamibi scans are valuable for identifying ectopic glands in tertiary hyperparathyroidism. This imaging technique shows high sensitivity and positive predictive value in surgical patients.
Area of Science:
- Endocrinology
- Nuclear Medicine
- Surgical Oncology
Background:
- Tertiary hyperparathyroidism is a complex endocrine disorder often requiring surgical intervention.
- Ectopic parathyroid glands can complicate surgical management and diagnosis.
Purpose of the Study:
- To evaluate the diagnostic utility of preoperative technetium Tc-99m sestamibi scintigraphy.
- To determine the incidence of ectopic parathyroid glands in tertiary hyperparathyroidism.
Main Methods:
- Prospective analysis of 21 patients with tertiary hyperparathyroidism undergoing parathyroidectomy.
- Collection of demographic data, scintigraphy results, gland location, and biochemical markers (calcium, parathyroid hormone).
Main Results:
- 43% of patients had ectopic parathyroid glands.
- Technetium Tc-99m sestamibi scintigraphy demonstrated an overall sensitivity of 76%.
- Sensitivity was comparable between patients with and without ectopic glands (78% vs. 75%).
Conclusions:
- Preoperative Tc-99m sestamibi scintigraphy is a sensitive and valuable tool for patients with tertiary hyperparathyroidism.
- The higher-than-expected incidence of ectopic glands underscores the importance of accurate preoperative localization.
Related Concept Videos
01:25Imaging Studies for Cardiovascular System VI: Calcium -Scoring CT
Calcium-Scoring CT ScanA calcium-scoring CT scan, also known as coronary artery calcium (CAC) scan, detects calcium deposits in the coronary arteries. This test assesses the risk of coronary artery disease (CAD), which can lead to cardiovascular events such as angina, heart failure, and sudden cardiac arrest.A calcium-scoring CT scan is generally recommended for individuals at intermediate risk of CAD without symptoms. It includes:Men aged 40-75 and women aged 50-75: Especially those with a...
01:25Imaging Studies II: Positron Emission Tomography and Scintigraphy
Positron Emission Tomography (PET) is a medical imaging technique that provides crucial insights into the body's physiological functions at a molecular level. It is an indispensable resource for diagnosing, staging, and monitoring various illnesses, notably cancer, neurological disorders, and cardiovascular conditions.
Fundamental Principles of PET
Fundamental Principles of PET
01:27Imaging Studies III: Computed Tomography
DefinitionComputed Tomography (CT) of the genitourinary (GU) tract is a non-invasive imaging modality that utilizes X-rays and computer processing to generate detailed cross-sectional images of the urinary system, encompassing the kidneys, ureters, bladder, and adjacent structures such as the adrenal glands.PurposeCT scans of the GU tract serve several diagnostic and therapeutic purposes, including:Diagnosis of Urinary Tract Diseases: Detects kidney stones, tumors, cysts, and congenital...
01:29Positron Emission Tomography
Positron emission tomography (PET) is a medical imaging technique involving radiopharmaceuticals — substances that emit short-lived radiation. Although the first PET scanner was introduced in 1961, it took 15 more years before radiopharmaceuticals were combined with the technique and revolutionized its potential.
One of the main requirements of a PET scan is a positron-emitting radioisotope, which is produced in a cyclotron and then attached to a substance used by the part of the body being...
One of the main requirements of a PET scan is a positron-emitting radioisotope, which is produced in a cyclotron and then attached to a substance used by the part of the body being...
01:13Radiological Investigation III: Pulmonary Angiogram and PET Scan
Radiological investigations are paramount in the diagnosis and management of various pulmonary diseases. Two essential investigations are the Pulmonary Angiogram and the Positron Emission Tomography (PET) Scan.
Pulmonary Angiogram
A Pulmonary Angiogram is an invasive procedure involving injecting a contrast medium through a catheter threaded into the pulmonary artery or the right side of the heart to visualize the pulmonary vasculature. Computed Tomography (CT) scans have mainly replaced this...
Pulmonary Angiogram
A Pulmonary Angiogram is an invasive procedure involving injecting a contrast medium through a catheter threaded into the pulmonary artery or the right side of the heart to visualize the pulmonary vasculature. Computed Tomography (CT) scans have mainly replaced this...
01:28Imaging Studies for Cardiovascular System V: CT
Cardiac computed tomography (CT) scanning is an advanced cardiac imaging technique that utilizes CT technology, with or without intravenous (IV) contrast, to produce accurate cross-sectional virtual slices of specific areas of the heart, coronary circulation, and major blood vessels such as the aorta, pulmonary veins, and arteries. The computer processes these slices to generate three-dimensional images. Multidetector CT (MDCT) is a rapid form of CT scanning that captures multiple slices...