[Determination of chlorphenamine and propantheline bromide in pukeling tablets by differential--linear combination...

This paper provides the basic principle and experimental technique of differential--linear combination equal value derivative spectrophotometry. Quantitative analysis of three or four component--mixture can be done without separation. This method was investigated to assay the contents of chlorphenamine and propantheline bromide in Pukeling tablets by using UV-210A spectrophotometer. The average recoveries of chlorphenamine and propantheline bromide were 100.2 +/- 1.49% (CV) and 99.89 +/- 1.03% (CV) respectively. The results showed that it not only can effectively remove disturbances from each other, but also give higher sensitivity and accuracy.