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Related Experiment Video

Updated: Jul 11, 2026

Assessment of Resistance to Tyrosine Kinase Inhibitors by an Interrogation of Signal Transduction Pathways by Antibody Arrays
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Published on: September 19, 2018

TSH signalling and cancer.

Custodia García-Jiménez1, Pilar Santisteban

  • 1Departamento de Ciencias de la Salud III, Universidad Rey Juan Carlos, Madrid, Spain.

Arquivos Brasileiros De Endocrinologia E Metabologia
|September 25, 2007
PubMed
Summary

Thyroid cancer often involves mutations in the thyrotropin receptor (TSHR). Functional TSHR is key in differentiated thyroid cancers, while undifferentiated types often have silenced TSHR, impacting therapeutic strategies.

Area of Science:

  • Endocrinology
  • Oncology
  • Molecular Biology

Background:

  • Thyroid cancers are common endocrine neoplasms with frequent thyrotropin receptor (TSHR) mutations.
  • TSHR's role in thyroid cancer is explored through classical and cancer stem cell theories.
  • Understanding TSHR alterations is crucial for thyroid cancer pathogenesis and treatment.

Purpose of the Study:

  • To review the current understanding of TSHR's role in thyroid cancer.
  • To update the database of cancer-related TSHR mutations.
  • To explore TSHR's signaling network and its implications in thyroid cancer evolution.

Main Methods:

  • Review of existing literature on TSHR and thyroid cancer.
  • Analysis of TSHR gene and protein structure.

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  • Database compilation of TSHR mutations in cancer.

    • Main Results:

    • Hyperfunctioning TSHR mutants are associated with differentiated thyroid cancers.
    • Undifferentiated thyroid cancers frequently exhibit silenced TSHR.
    • TSHR signaling integrates with proliferative pathways like Wnt, PI3K, and MAPK.

    Conclusions:

    • TSHR alterations' role in thyroid cancer onset versus evolution requires further investigation.
    • Functional TSHR presents therapeutic opportunities.
    • Epigenetic modifications of TSHR may offer new avenues for treating undifferentiated thyroid carcinomas.