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Peripheral blood flow control in diabetes mellitus
1Department of Internal Medicine & Endocrinology, Hvidovre Hospital, Denmark.
Acta Physiologica Scandinavica. Supplementum
|January 1, 1991
Summary
Long-term diabetes impairs peripheral circulation through angiopathy and autonomic neuropathy. This affects blood vessel function and regulation, with consequences still needing full establishment.
Area of Science:
- Cardiovascular physiology
- Diabetic complications
- Peripheral circulation
Background:
- Long-term diabetes mellitus significantly impacts peripheral circulation.
- This impact is attributed to diabetic angiopathy and autonomic neuropathy.
- These conditions affect vascular autoregulation, distensibility, and reflex control of vascular resistance.
Purpose of the Study:
- To investigate the consequences of impaired autoregulation and distensibility in diabetic peripheral circulation.
- To further understand the pathophysiology of circulatory dysfunction in diabetes.
Main Methods:
- The study reviews existing literature on the hemodynamic effects of vascular denervation in diabetes.
- It highlights known consequences like blood pressure maladaptation to stimuli.
- It identifies the need for further research into autoregulation and distensibility disturbances.
Main Results:
- Hemodynamic consequences of vascular denervation in diabetes are well-documented.
- Blood pressure maladaptation to stimuli such as standing and exercise is a known outcome.
- The specific consequences of altered autoregulation and distensibility remain less understood.
Conclusions:
- Diabetic angiopathy and autonomic neuropathy are key factors in peripheral circulatory dysfunction.
- While denervation effects are known, the impact of impaired autoregulation and distensibility requires further investigation.
- Establishing these consequences is crucial for a comprehensive understanding of diabetic cardiovascular complications.