Temperature measurement on tissue surface during laser irradiation.

Area of Science:

• Biomedical Engineering
• Optical Imaging
• Cancer Therapy

Background:

• Photothermal therapy effectiveness relies on precise temperature control at the treatment site.
• Infrared thermography offers a non-invasive method to monitor tissue surface temperature during treatment.

Purpose of the Study:

• To investigate the correlation between surface temperature distribution and photothermal therapy efficacy.
• To validate theoretical models against experimental thermographic data for laser tumor treatment.
• To explore the combined effects of indocyanine green enhancement and immunoadjuvants on selective photothermal interaction.

Main Methods:

• Utilized infrared thermography to capture real-time thermal images of gel phantoms and animal tumors during laser irradiation.
• Employed Monte Carlo simulations for light absorption and finite difference methods for heat diffusion to model temperature distribution.
• Administered intratumoral indocyanine green and an immunoadjuvant to enhance selective photothermal effects and immune responses.

Main Results:

• Theoretical simulations and experimental thermographic measurements showed strong agreement in predicting surface temperature distribution.
• Demonstrated that surface temperature of irradiated tissue can be effectively controlled using dye and adjuvant enhancement.
• Confirmed the potential of tissue temperature profiles to guide selective photothermal treatment, especially when combined with immunotherapy.

Conclusions:

• Surface temperature monitoring is a reliable indicator for optimizing laser photothermal therapy parameters and treatment outcomes.
• The integration of indocyanine green, immunoadjuvants, and temperature feedback offers a promising approach for targeted tumor ablation.
• This method provides a foundation for guided immunotherapy by precisely controlling thermal effects within the tumor microenvironment.