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Updated: Jul 11, 2026

Microelectrode Array Recording of Sinoatrial Node Firing Rate to Identify Intrinsic Cardiac Pacemaking Defects in Mice
Published on: July 5, 2021
Isolated sinus node dysfunction in an infant with developmental delay
Timothy C Slesnick1, Naomi J Kertesz, Jack F Price
1Department of Pediatrics, Baylor College of Medicine, The Lillie Frank Abercrombie Section of Cardiology, Houston, TX, USA. ts692171@bcm.tmc.edu
Insights
This case study details an infant with developmental delay and prolonged sinus pauses who experienced cardiac arrest. Pacemaker implantation was recommended due to the severity of the sinus pauses and cardiac arrest event.
Area of Science:
- Pediatric Cardiology
- Neonatal Neurology
Background:
- Developmental delay in infants can have various underlying causes.
- Sinus pauses are a type of cardiac arrhythmia where the heart's natural pacemaker (sinoatrial node) fails to fire properly.
Observation:
- An infant presented with developmental delay and a structurally normal heart.
- The infant experienced prolonged sinus pauses, with durations up to 15 seconds.
- The infant suffered an unmonitored cardiac arrest during hospitalization.
Findings:
- Despite investigation, the definitive etiology of the prolonged sinus pauses remained undetermined.
- The infant's history of cardiac arrest and significant sinus pause duration were critical factors.
Implications:
- Physicians recommended pacemaker implantation for the infant due to the cardiac arrest and severe sinus pauses.
- The family opted for pacemaker implantation prior to hospital discharge.
- This case highlights the importance of investigating unexplained sinus pauses in infants, even with a structurally normal heart.
Abstract:
We present a case of an infant with developmental delay, a structurally normal heart, and prolonged sinus pauses that suffered an unmonitored cardiac arrest while in the hospital. An investigation into the etiology of her sinus pauses did not reveal a definitive cause, and she continued to have pauses up to 15 s in duration. Her history of the cardiac arrest and the duration of the pauses guided the physicians' recommendations and the family's decision to undergo pacemaker implantation prior to discharge from the hospital.
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