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Related Experiment Video

Updated: Jul 11, 2026

Subcutaneous Infection of Methicillin Resistant Staphylococcus Aureus (MRSA)
12:18

Subcutaneous Infection of Methicillin Resistant Staphylococcus Aureus (MRSA)

Published on: February 9, 2011

PVL-positive MRSA in Austria.

K Krziwanek1, C Luger, B Sammer

  • 1National Reference Centre for Nosocomial Infections and Antibiotic Resistance, Department of Hygiene, Microbiology and Tropical Medicine, Elisabethinen Hospital, Fadingerstrasse 1, Linz, Austria. karina.krziwanek@elisabethinen.or.at

European Journal of Clinical Microbiology & Infectious Diseases : Official Publication of the European Society of Clinical Microbiology
|September 25, 2007
PubMed
Summary

Panton-Valentine leukocidin (PVL)-positive methicillin-resistant Staphylococcus aureus (MRSA) strains are spreading in Austria, particularly among younger individuals. This study provides the first overview of these PVL-positive MRSA strains in the country.

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Last Updated: Jul 11, 2026

Subcutaneous Infection of Methicillin Resistant Staphylococcus Aureus (MRSA)
12:18

Subcutaneous Infection of Methicillin Resistant Staphylococcus Aureus (MRSA)

Published on: February 9, 2011

Area of Science:

  • Microbiology
  • Infectious Diseases
  • Epidemiology

Background:

  • Methicillin-resistant Staphylococcus aureus (MRSA) poses a significant public health threat globally.
  • Panton-Valentine leukocidin (PVL) is a toxin produced by some S. aureus strains, often associated with severe infections.
  • Understanding the prevalence and characteristics of PVL-positive MRSA is crucial for effective control strategies.

Purpose of the Study:

  • To provide the first comprehensive overview of Panton-Valentine leukocidin (PVL)-positive methicillin-resistant Staphylococcus aureus (MRSA) strains circulating in Austria.
  • To compare the epidemiological situation of PVL-positive MRSA in Austria with international data.
  • To identify common sequence types and prevalence rates of PVL-positive MRSA.

Main Methods:

  • Analysis of 1150 MRSA isolates (from infections and colonisation) collected between 2001 and 2006 in Austria.
  • Detection of Panton-Valentine leukocidin (PVL) genes in MRSA isolates.
  • Multilocus sequence typing (MLST) to determine the genetic relatedness of PVL-positive MRSA strains.

Main Results:

  • Ninety-four PVL-positive MRSA strains were identified, representing a notable prevalence.
  • The most common sequence types (STs) among PVL-positive MRSA were ST8, ST152, ST30, ST80, and ST5, with ST22 and ST777 also detected.
  • PVL-positive MRSA isolates showed a higher prevalence in younger patients compared to nosocomial MRSA, which predominantly affected the elderly.
  • Two PVL-positive MRSA strains identified in Austria were not yet widespread in Western Europe, indicating unique local clonal spread.

Conclusions:

  • A relatively high prevalence of PVL-positive MRSA strains was observed in Austria during the study period.
  • Several MRSA clones carrying PVL genes are actively spreading within Austria.
  • The findings highlight the emergence of specific PVL-positive MRSA clones in Austria, necessitating ongoing surveillance and targeted interventions.