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Updated: Jul 11, 2026

Formation of Dispersible Taohong Siwu Tablets
Published on: February 3, 2023
Investigation of hypromellose particle size effects on drug release from sustained release hydrophilic matrix tablets
Shawn A Mitchell1, Karen M Balwinski
1Water Soluble Polymers, The Dow Chemical Company, Midland, MI 48674, USA. samitchell@dow.com
Abstract:
Selected combinations of six model drugs and four hypromellose (USP 2208) viscosity grades were studied utilizing direct compression and in vitro dissolution testing. Experimental HPMC samples with differing particle size distributions (coarse, fine, narrow, bimodal) were generated by sieving. For some formulations, the impact of HPMC particle size changes was characterized by faster drug release and an apparent shift in drug release mechanism when less than 50% of the HPMC passed through a 230 mesh (63 microm) screen. Within the ranges studied, drug release from other formulations appeared to be unaffected by HPMC particle size changes.
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