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Related Experiment Video

Updated: Jul 11, 2026

Dissection of the Auditory Bulla in Postnatal Mice: Isolation of the Middle Ear Bones and Histological Analysis
07:40

Dissection of the Auditory Bulla in Postnatal Mice: Isolation of the Middle Ear Bones and Histological Analysis

Published on: January 4, 2017

Mouse models to study inner ear development and hereditary hearing loss.

Lilach M Friedman1, Amiel A Dror, Karen B Avraham

  • 1Department of Human Molecular Genetics and Biochemistry, Sackler School of Medicine, Tel Aviv University, Tel Aviv, Israel.

The International Journal of Developmental Biology
|September 25, 2007
PubMed
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Mouse models are crucial for understanding hereditary sensorineural hearing loss. Research using these models helps identify new genes linked to hearing impairment and inner ear function.

Area of Science:

  • Genetics
  • Otolaryngology
  • Developmental Biology

Background:

  • Hereditary sensorineural hearing loss is a common disability, affecting 1 in 1,000 children, with higher prevalence in isolated communities.
  • Inner ear defects are the primary cause of this condition.
  • Mice are valuable animal models for studying human hearing loss genetics and mechanisms.

Purpose of the Study:

  • To review mouse models of genes associated with human hearing impairment.
  • To highlight the role of these models in elucidating inner ear function.
  • To discuss the potential of ongoing genomic projects for future gene discovery.

Main Methods:

  • Review of existing literature on mouse models for deafness-related genes.
  • Analysis of studies demonstrating the functional significance of identified genes in vivo.

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Last Updated: Jul 11, 2026

Dissection of the Auditory Bulla in Postnatal Mice: Isolation of the Middle Ear Bones and Histological Analysis
07:40

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Published on: January 4, 2017

Evaluation of Planar-Cell-Polarity Phenotypes in Ciliopathy Mouse Mutant Cochlea
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Evaluation of Planar-Cell-Polarity Phenotypes in Ciliopathy Mouse Mutant Cochlea

Published on: February 21, 2016

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Dissection of the Endolymphatic Sac from Mice

Published on: March 29, 2021

  • Discussion of large-scale mouse mutagenesis projects (KOMP, EUCOMM).

    • Main Results:

    • Mutant mouse models have revealed the function of genes involved in the tectorial membrane (collagens, tectorins) and hair cell structure (stereocilia, kinocilia).
    • Studies in mice underscore the importance of endolymph composition and specific proteins (e.g., prestin, myosins) for inner ear function.
    • Mouse models have been instrumental in understanding the mechanisms underlying hereditary hearing loss.

    Conclusions:

    • Mouse models are essential for identifying novel deafness genes and understanding their in vivo roles.
    • Ongoing systematic projects are expected to significantly expand the repertoire of available mouse models for human deafness.
    • These models will accelerate research into the diverse causes of hearing impairment and facilitate the development of targeted therapies.