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Updated: Jul 11, 2026
07:54
Drug-Induced Sleep Endoscopy (DISE) with Target Controlled Infusion (TCI) and Bispectral Analysis in Obstructive Sleep Apnea
Published on: December 6, 2016
NT-proBNP is not elevated in patients with obstructive sleep apnoea
Ralf-Harto Hübner1, Nour Eddine El Mokhtari, Sandra Freitag
1Department of Internal Medicine, University Hospital Schleswig-Holstein, Campus Kiel, Schittenhelmstrasse 12, 24105 Kiel, Germany.
Respiratory Medicine
|September 26, 2007
Summary
N-terminal pro-brain natriuretic peptide (NT-ProBNP) levels do not correlate with obstructive sleep apnoea syndrome (OSAS) severity. NT-ProBNP is not a reliable biomarker for cardiovascular issues in OSAS patients.
Area of Science:
- Cardiology
- Sleep Medicine
- Biomarkers
Background:
- N-terminal pro-brain natriuretic peptide (NT-ProBNP) is a marker for cardiac stress and dysfunction.
- Cardiac dysfunction is potentially linked to obstructive sleep apnoea syndrome (OSAS).
Purpose of the Study:
- To investigate the association between NT-ProBNP levels and OSAS.
- To determine if NT-ProBNP can serve as a biomarker for cardiovascular abnormalities in OSAS patients.
Main Methods:
- Evaluated plasma NT-ProBNP in 60 patients with suspected OSAS.
- Measurements included NT-ProBNP levels, polysomnography, and echocardiography.
- Patients received positive airway pressure treatment, with reassessment of NT-ProBNP and polysomnography after three months.
Main Results:
- NT-ProBNP levels showed no association with apnoea-hypopnoea index (AHI) or other sleep indices.
- Multiple regression analysis revealed NT-ProBNP correlated with left ventricular ejection fraction, creatinine clearance, and hypertension, but not AHI.
Conclusions:
- NT-ProBNP is not significantly associated with OSAS.
- NT-ProBNP cannot be reliably used as a sensitive marker for cardiovascular abnormalities in patients diagnosed with OSAS.
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