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Related Experiment Videos

Within-session practice effect on paced auditory serial addition test in multiple sclerosis.

G Nagels1, M B D'hooghe, D Kos

  • 1Laboratory of Neurochemistry and Behaviour, Institute Born-Bunge, University of Antwerp, Universiteitsplein 1, 2610 Antwerp, Belgium.

Multiple Sclerosis (Houndmills, Basingstoke, England)
|September 26, 2007
PubMed
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Practice effects occur during the Paced Auditory Serial Addition Test (PASAT) in multiple sclerosis (MS) patients. Both relapsing remitting and secondary progressive MS patients showed improved scores and subsequent fatigue within a single testing session.

Area of Science:

  • Neuroscience
  • Clinical Psychology

Background:

  • The Paced Auditory Serial Addition Test (PASAT) is a common cognitive assessment tool in multiple sclerosis (MS) research.
  • Repeated administrations of the PASAT at short intervals can lead to practice effects, potentially confounding study results.

Purpose of the Study:

  • To investigate intra-session practice effects of the PASAT in patients with relapsing remitting (RR) and secondary progressive (SP) multiple sclerosis.
  • To assess potential fatigability during the PASAT within a single testing session.

Main Methods:

  • Seventy RR-MS and 40 SP-MS patients completed two PASAT runs within a single session.
  • Performance was analyzed for changes between the first and second runs, and between the first and second halves of each run.
  • Difficulty and discrimination of items with answers greater than 9 were evaluated.

Related Experiment Videos

  • A simulation explored the validity of a simplified scoring method for fMRI studies.

    • Main Results:

    • A significant increase in correct PASAT answers was observed from the first to the second run in both RR-MS and SP-MS groups.
    • Both patient groups exhibited a decrease in PASAT scores from the first to the second half of each test run, indicating fatigability.
    • Items requiring answers greater than 9 were more difficult but had similar discrimination ability.
    • A simplified scoring method was supported by simulation for fMRI applications.

    Conclusions:

    • Intra-session practice effects are evident in the PASAT for both RR-MS and SP-MS patients.
    • Fatigability during the PASAT is also a significant factor within a single testing session for these patient groups.
    • These findings highlight the need to consider practice and fatigue effects when designing MS cognitive studies using the PASAT.