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Feeling sounds after a thalamic lesion.

Tony Ro1, Alessandro Farnè, Ruth M Johnson

  • 1Department of Psychology, Rice University, Houston, TX 77005-1892, USA. tro@rice.edu

Annals of Neurology
|September 26, 2007
PubMed
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The ventrolateral nucleus (VL) of the thalamus, typically linked to motor control, is shown to be crucial for sensory processing. Damage to the VL can lead to altered sensory perception and synesthesia.

Area of Science:

  • Neuroscience
  • Thalamic research
  • Sensory processing

Background:

  • The ventrolateral nucleus (VL) of the thalamus has historically been associated with motor functions due to its connections with the cerebellum and motor cortex.
  • This study investigates the role of the human VL beyond motor control, exploring its involvement in sensory processing.

Observation:

  • A patient with a lesion restricted to the right VL exhibited contralesional sensory processing deficits.
  • Initial observations revealed a phenomenon termed 'unisensory antiextinction,' where sensory events were more readily detected on the contralesional side under specific unisensory conditions.
  • Over time, this evolved into a form of synesthesia, with auditory stimuli eliciting tactile perceptions.

Findings:

  • Structural and diffusion tensor imaging identified a lesion in the right VL.

Related Experiment Videos

  • Behavioral assessments demonstrated significant alterations in somatosensory and visual processing.
  • Tractography revealed modified thalamocortical connections originating from the lesioned VL, correlating with the observed sensory changes.

    • Implications:

    • The findings establish a significant role for the ventrolateral nucleus (VL) in human sensory processing.
    • Reorganization of thalamocortical connectivity following VL damage can induce profound alterations in perceptual experiences.
    • This highlights the plasticity of thalamocortical networks and their capacity to mediate complex sensory functions.