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Thyroid dysfunction in women with systemic sclerosis.

Bianca Marasini1, Pier Alda Ferrari, Nadia Solaro

  • 1Rheumatology Unit, Humanitas Clinical Institute, University of Milan, Milan, Italy.

Annals of the New York Academy of Sciences
|September 26, 2007
PubMed
Summary
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Systemic sclerosis (SSc) does not independently increase thyroid dysfunction risk. However, antithyroid peroxidase antibodies indicate a higher risk for hypothyroidism in both SSc and osteoarthritis patients.

Area of Science:

  • Rheumatology
  • Endocrinology
  • Immunology

Background:

  • Hypothyroidism is frequently reported in systemic sclerosis (SSc), but its independent association with SSc remains debated.
  • Thyroid dysfunction screening in SSc patients is a topic of ongoing discussion.

Purpose of the Study:

  • To investigate whether systemic sclerosis (SSc) independently elevates the risk of thyroid dysfunction.
  • To determine the necessity of routine thyroid function screening in SSc patients.

Main Methods:

  • Serum thyroid function tests (free triiodothyronine, free thyroxine, thyroid-stimulating hormone) and thyroid autoantibodies (antithyroid peroxidase, antithyreoglobulin) were measured.
  • Compared 79 women with SSc against 81 age-matched women with osteoarthritis (OA) as controls.

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Main Results:

  • Hypothyroidism prevalence was 20% in SSc and 11% in OA (P=0.131).
  • Antithyroid peroxidase antibodies were more frequent in SSc (23%) than OA (11%) (P=0.057).
  • The risk of hypothyroidism was significantly higher in antithyroid peroxidase-positive individuals, particularly in the OA group (OR=24.6) compared to the SSc group (OR=4.2).

Conclusions:

  • Systemic sclerosis (SSc) is not an independent risk factor for thyroid dysfunction.
  • Antithyroid peroxidase antibodies are a key indicator for identifying patients at risk of developing thyroid dysfunction, regardless of their primary condition.