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Efficacy of dantrolene sodium in the treatment of spasticity
1Neurology and Physical Medicine Services, Veterans Administration Hospital, and Department of Neurology, State University of New York, Upstate Medical Center, Syracuse, NY 13210, USA.
Abstract:
Dantrolene sodium was effective in controlling spasticity and improving function in 11 of 13 patients taking part in a 14-week double-blind crossover study. Clonus and lower-extremity tendon jerks were reduced in almost all patients (10 and 11 respectively) during dantrolene sodium therapy at 200 to 400 mg/day. Activities of daily living showed marked improvement in 3 cases and moderate improvement in 8. All 13 patients reported decreases in the frequency of intermittent painful spasm. Side effects were minimal and consisted mainly of an initial 3- to 4-day period of weakness and lightheadedness.
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