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Etanercept associated optic neuropathy.

Vicky Chang, Deborah McCurdy, Lynn K Gordon

    Clinical & Experimental Ophthalmology
    |September 27, 2007
    PubMed
    Summary
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    Etanercept, a biologic therapy, may cause optic neuropathy, a rare but serious side effect. Prompt eye exams are crucial for patients on anti-tumor necrosis factor-alpha antagonists.

    Area of Science:

    • Ophthalmology
    • Rheumatology
    • Immunology

    Background:

    • Biologic therapies, such as anti-tumor necrosis factor-alpha (anti-TNF-alpha) agents, are widely used for inflammatory conditions.
    • Etanercept is a common anti-TNF-alpha antagonist.
    • Optic neuropathy is a potential, albeit rare, adverse event associated with these therapies.

    Observation:

    • A 14-year-old male patient developed optic neuropathy after initiating etanercept treatment.
    • This case adds to the 15 previously reported instances of anti-TNF-alpha-associated optic neuropathy.

    Findings:

    • The report reviews the characteristics of 15 previously documented cases of anti-TNF-alpha-associated optic neuropathy.
    • Potential pathophysiologic mechanisms underlying this adverse event are discussed.

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    Implications:

    • The findings underscore the critical need for ophthalmologic evaluation in patients experiencing visual disturbances while on anti-TNF-alpha therapy.
    • Early detection and intervention may be vital for managing visual changes associated with biologic treatments.