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Intracranial hypertension is a sustained elevation of intracranial pressure (ICP) above 22 mm Hg. In supine adults, normal ICP is ~7–15 mm Hg.The rigid, nonexpandable cranium contains three components—brain tissue, blood, and cerebrospinal fluid (CSF)—that total ~1,700 mL in a typical adult: 1,400 mL brain (~80%), 150 mL blood (~10%), and 150 mL CSF (~10%). According to the Monro–Kellie doctrine, total intracranial volume is effectively fixed. When one component expands, CSF and venous blood...

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Establishment of a Modified Ferric Chloride-Induced Superior Sagittal Sinus Thrombosis

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Published on: December 30, 2025

Cranial sinus thrombosis and preeclampsia.

C A Koch¹, J A Robyn, E T Walz

¹Department of Medicine The Ohio State University Medical Center, Columbus, OH, USA; Department of Neurology, The Ohio State University Medical Center, Columbus, OH, USA.

Journal of Stroke and Cerebrovascular Diseases : the Official Journal of National Stroke Association

|September 27, 2007

Summary

Preeclampsia may increase the risk of cranial sinus thrombosis (CST) during pregnancy. This case study highlights the potential role of proteinuria in the development of CST in preeclamptic women, emphasizing a critical link between these conditions.

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Area of Science:

Obstetrics and Gynecology
Neurology
Nephrology

Background:

Cranial sinus thrombosis (CST) is a recognized complication during pregnancy and the postpartum period.
A substantial percentage of women with CST have a history of preeclampsia.
Nephrotic syndrome is known to be linked with hypercoagulable states.

Purpose of the Study:

To investigate the potential association between preeclampsia and cranial sinus thrombosis.
To explore the pathogenetic role of proteinuria in the development of CST in a preeclamptic patient.

Main Methods:

Case report of a 23-year-old gravida III, para I woman.
Clinical presentation and diagnostic workup for preeclampsia and CST.
Literature review on CST in pregnancy and its association with preeclampsia.

Main Results:

The patient presented with preeclampsia and subsequently developed cranial sinus thrombosis.
Proteinuria was a significant clinical finding in this patient.
Literature review indicated a notable prevalence of preeclampsia among CST patients.

Conclusions:

Preeclampsia may be a risk factor for developing cranial sinus thrombosis.
Proteinuria might play a crucial pathogenetic role in the occurrence of CST in preeclamptic women.
Further research is warranted to elucidate the relationship between preeclampsia, proteinuria, and CST.