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Updated: Jul 11, 2026

Determining the Functional Status of the Corticospinal Tract Within One Week of Stroke

Determining the Functional Status of the Corticospinal Tract Within One Week of Stroke

Published on: February 22, 2020

The initial acute phase response predicts long-term stroke recovery.

W M Clark, N B Beamer, M Wynn

Journal of Stroke and Cerebrovascular Diseases : the Official Journal of National Stroke Association

|September 27, 2007

Summary

Acute phase response indicators, such as IL-6 and albumin, show strong correlation with long-term stroke recovery. These biological markers offer valuable insights comparable to traditional clinical predictors for predicting patient outcomes after ischemic stroke.

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A Preclinical Model to Assess Brain Recovery After Acute Stroke in Rats

A Preclinical Model to Assess Brain Recovery After Acute Stroke in Rats

Published on: November 6, 2019

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Last Updated: Jul 11, 2026

Determining the Functional Status of the Corticospinal Tract Within One Week of Stroke

Determining the Functional Status of the Corticospinal Tract Within One Week of Stroke

Published on: February 22, 2020

A Preclinical Model to Assess Brain Recovery After Acute Stroke in Rats

A Preclinical Model to Assess Brain Recovery After Acute Stroke in Rats

Published on: November 6, 2019

Area of Science:

Neurology
Immunology
Biomarkers

Background:

Acute phase response (APR) indicators correlate with infarct size and recurrence in acute ischemic stroke.
Predicting long-term stroke recovery is crucial for patient management and rehabilitation.

Purpose of the Study:

To compare the predictive power of APR indicators versus standard clinical predictors for 6-month stroke recovery.
To assess the correlation of plasma IL-6, fibrinogen, WBCs, and serum albumin with long-term stroke outcomes.

Main Methods:

Measured plasma levels of IL-6, fibrinogen, WBCs, and albumin in 131 ischemic stroke patients within 4 days of onset.
Utilized standard clinical predictors: NIHSS, CT infarct size, and initial Glasgow scale.
Performed correlation and multiple regression analyses to compare predictive values for 6-month Glasgow outcome.

Main Results:

Individual APR indicators showed significant correlations with 6-month Glasgow outcome (IL-6: 0.42, Albumin: 0.47).
Multiple regression analysis indicated APR indicators explained 31% of the variance in recovery (adjusted R² = .31).
Clinical variables explained 38% of the variance (adjusted R² = .38), showing comparable predictive power to APR indicators.

Conclusions:

Initial acute phase response indicators are strongly correlated with 6-month stroke recovery.
APR markers provide valuable prognostic information for ischemic stroke patients.
These biological markers approach the predictive accuracy of established clinical assessments for stroke recovery.