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Related Experiment Video

Updated: Jul 11, 2026

Quantification of Autoreactive Antibodies in Mice upon Experimental Autoimmune Encephalomyelitis

Quantification of Autoreactive Antibodies in Mice upon Experimental Autoimmune Encephalomyelitis

Published on: December 1, 2023

Hashimot's encephalopathy-response to intravenous immunoglobulin.

E Wirkowski¹, R B Libman, M Batash

¹Department of Neurology, Long Island Jewish Medical Center, New Hyde Park, NY, USA.

Journal of Stroke and Cerebrovascular Diseases : the Official Journal of National Stroke Association

|September 27, 2007

Summary

Hashimoto's encephalopathy, a rare brain disorder, may be treatable with intravenous immunoglobulin (IVIG). This approach showed significant improvement in a patient unresponsive to traditional therapies, offering a potentially safer alternative.

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Published on: April 9, 2012

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Last Updated: Jul 11, 2026

Quantification of Autoreactive Antibodies in Mice upon Experimental Autoimmune Encephalomyelitis

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Overcoming Unresponsiveness in Experimental Autoimmune Encephalomyelitis (EAE) Resistant Mouse Strains by Adoptive Transfer and Antigenic Challenge

Overcoming Unresponsiveness in Experimental Autoimmune Encephalomyelitis (EAE) Resistant Mouse Strains by Adoptive Transfer and Antigenic Challenge

Published on: April 9, 2012

Area of Science:

Neurology
Immunology
Endocrinology

Background:

Hashimoto's encephalopathy is a rare neurological disorder characterized by cerebral dysfunction, potentially mimicking stroke.
Current treatments involve steroids and immunosuppression, which can have significant side effects.
Exploring alternative, less toxic treatments like IVIG is crucial for patient management.

Purpose of the Study:

To evaluate the efficacy of intravenous immunoglobulin (IVIG) as a treatment for Hashimoto's encephalopathy.
To present a case study of an elderly patient with Hashimoto's encephalopathy treated with IVIG.

Main Methods:

A case report of an 82-year-old woman presenting with neurological deficits and elevated antithyroid antibodies.
Initial treatment with prednisone and methotrexate proved ineffective.
Subsequent treatment involved monthly courses of IVIG.

Main Results:

The patient experienced marked clinical improvement following IVIG treatment.
This suggests IVIG may be an effective therapeutic option for Hashimoto's encephalopathy.

Conclusions:

Hashimoto's encephalopathy might be underdiagnosed.
Intravenous immunoglobulin (IVIG) should be considered as a treatment option for patients diagnosed with Hashimoto's encephalopathy, offering a potentially beneficial alternative to conventional therapies.