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Published on: May 14, 2013
Stroke outcome in patients already taking aspirin
Summary
Aspirin (ASA) use before stroke did not reduce stroke severity in a study of first-time ischemic stroke patients. Further research is needed to definitively settle this question for stroke treatment trials.
Area of Science:
- Neurology
- Cardiovascular Medicine
- Clinical Research
Background:
- Aspirin (ASA) is established for secondary stroke prevention.
- Evidence on ASA's impact on stroke severity is conflicting.
- Prior ASA use may influence stroke outcomes.
Purpose of the Study:
- To investigate if aspirin therapy initiated before stroke onset reduces stroke severity.
- To analyze the effect of pre-stroke aspirin use on acute ischemic stroke outcomes.
Main Methods:
- Prospective data collection from 178 first acute ischemic stroke patients (July 1996-July 1998).
- Assessed stroke severity using National Institutes of Health Stroke Scale (NIHSS), Barthel Index (BI), Modified Rankin Scale (MRS), and Glasgow Outcome Scale (GOS).
- Compared outcomes between patients taking aspirin (n=42) and those not (n=136).
Main Results:
- No significant differences in demographic or clinical characteristics between aspirin users and non-users.
- No significant differences in NIHSS, BI, MRS, or GOS scores at admission or discharge.
- Aspirin use prior to stroke did not correlate with reduced stroke severity.
Conclusions:
- Current data do not support the hypothesis that pre-stroke aspirin use lessens stroke severity.
- Prudent to balance recent aspirin use in acute stroke treatment trials until definitively settled.
- Further investigation is warranted to clarify aspirin's role in stroke severity.
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