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Relations of adipose tissue CIDEA gene expression to basal metabolic rate, energy restriction, and obesity:

Anders Gummesson1, Margareta Jernås, Per-Arne Svensson

  • 1Department of Molecular and Clinical Medicine and Wallenberg Laboratory for Cardiovascular Research, Institute of Medicine, the Sahlgrenska Academy, Göteborg University, SE-413 45 Göteborg, Sweden anders.gummesson@gu.se

The Journal of Clinical Endocrinology and Metabolism
|September 27, 2007
PubMed
Abstract

Insights

Cell death-inducing DNA fragmentation factor-alpha-like effector A (CIDEA) gene expression in human adipose tissue is inversely linked to basal metabolic rate. This suggests CIDEA plays a role in regulating energy expenditure and may be a target for obesity treatment.

Area of Science:

  • Metabolic Research
  • Obesity Studies
  • Gene Expression Analysis

Background:

  • Cell death-inducing DNA fragmentation factor-alpha-like effector A (CIDEA) is implicated in inhibiting brown adipose tissue uncoupling in rodents.
  • This suggests CIDEA may be a potential therapeutic target for obesity by modulating metabolic rate.

Purpose of the Study:

  • To investigate the association between CIDEA and basal metabolic rate in humans.
  • To further elucidate the role of CIDEA in human obesity.

Main Methods:

  • CIDEA gene expression was analyzed in adipose tissue from two human studies: a cross-sectional study (n=92) and a longitudinal very low-calorie diet (VLCD) intervention study (n=24).
  • Body composition, metabolic rate, and uncoupling protein 1 expression were also assessed.

Main Results:

  • CIDEA gene was primarily expressed in human adipocytes.
  • Adipose tissue CIDEA expression was inversely correlated with basal metabolic rate, independent of body composition, age, and gender.
  • VLCD treatment increased CIDEA expression, which decreased upon refeeding. Reduced CIDEA expression correlated with higher body fat and insulin levels.
  • Uncoupling protein 1 expression was reduced during VLCD and inversely associated with CIDEA expression.

Conclusions:

  • Findings support CIDEA's role in adipose tissue energy expenditure.
  • CIDEA may be a key regulator of metabolic rate in humans.
  • Further research into CIDEA as an obesity target is warranted.

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