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Updated: Jul 11, 2026
13:08
Measurement of Factor V Activity in Human Plasma Using a Microplate Coagulation Assay
Published on: September 9, 2012
Multifactorial thrombophilia in a pregnancy: a case report
Ilknur Inegol Gumus1, Hilal Uslu, Nuket Bavbek
1Department of Obstetrics and Gynecology, Fatih University Faculty of Medicine, Ankara, Turkey. ilknurinegol@yahoo.com
Summary
Thrombophilias, or blood clotting disorders, significantly increase the risk of pregnancy complications like recurrent pregnancy loss. This case highlights multiple thrombophilic defects in a patient with a history of pregnancy loss.
Area of Science:
- Obstetrics and Gynecology
- Hematology
- Genetics
Background:
- Thrombophilias are conditions predisposing to blood clots (thromboembolism).
- These disorders are linked to adverse obstetric outcomes, including recurrent pregnancy loss.
- A significant percentage of unexplained recurrent pregnancy loss cases are associated with thrombophilic defects.
Observation:
- A pregnant woman with a history of recurrent pregnancy losses presented with complications.
- Her condition was complicated by a combination of thrombophilic factors.
- These included protein S deficiency, factor V Leiden mutation, methylene tetrahydrofolate reductase mutation, and antiphospholipid syndrome.
Findings:
- Thrombophilic defects are found in 49% to 65% of women with pregnancy complications.
- This represents a 3- to 8-fold increased risk compared to women with normal pregnancies.
- The patient presented with multiple co-existing thrombophilic conditions.
Implications:
- Early screening for thrombophilias in women with recurrent pregnancy loss is crucial.
- Identifying these defects can guide management strategies to improve pregnancy outcomes.
- This case underscores the complex interplay of genetic and acquired thrombophilias in obstetric complications.
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