Related Experiment Video

Updated: Jul 11, 2026

Development of a Neonatal Piglet Acute Lung Injury Model Recreating the Early Environment of Preterm Infant Lungs
08:58

Development of a Neonatal Piglet Acute Lung Injury Model Recreating the Early Environment of Preterm Infant Lungs

Published on: October 31, 2025

[Bronhopulmonary dysplasia]

Teresa Farstad1, Dag Bratlid

  • 1Barne- og ungdomsklinikken, Akershus universitetssykehus, 1478 Lørenskog. teresa.farstad@ahus.no

Tidsskrift for Den Norske Laegeforening : Tidsskrift for Praktisk Medicin, Ny Raekke
|September 27, 2007
PubMed

Insights

Bronchopulmonary dysplasia (BPD) remains a significant complication for premature infants, particularly those born weighing less than 1000g. Despite advances, its multifactorial etiology and limited treatment success highlight ongoing challenges in neonatal care.

Area of Science:

  • Neonatology
  • Pediatric Pulmonology
  • Perinatal Medicine

Context:

  • Bronchopulmonary dysplasia (BPD) is a chronic lung disease affecting premature infants.
  • While severe BPD is less common in infants born after 32 weeks gestation, it remains a frequent complication of severe prematurity.
  • Between 40-60% of infants weighing < 1000g at birth are diagnosed with BPD, depending on criteria.

Purpose:

  • To review recent publications on bronchopulmonary dysplasia (BPD).
  • To discuss the etiology, prophylaxis, management, and diagnostic criteria of BPD.
  • To highlight current understanding and challenges in BPD research and clinical practice.

Summary:

  • BPD is a multifactorial condition influenced by prematurity, intrauterine factors, genetics, inflammation, oxygen toxicity, and ventilator treatment.
  • The exact etiology of BPD is not fully understood, as it can occur in infants with minimal or no ventilatory support.
  • Current strategies for BPD prevention and treatment have shown limited success.

Impact:

  • Understanding the multifactorial nature of BPD is crucial for developing targeted prevention and treatment strategies.
  • Further research is needed to elucidate the complex etiology of BPD and improve outcomes for extremely premature infants.
  • This review provides a foundation for future investigations into novel therapeutic approaches for BPD.
Abstract

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