Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Insulin: Dosing Regimen and Adverse Effects01:16

Insulin: Dosing Regimen and Adverse Effects

Insulin-replacement therapy usually includes both long-acting insulin (basal) and short-acting insulin (to cater to postprandial needs). In a diverse group of type 1 diabetes patients, the average daily insulin dose is typically 0.5-0.7 units/kg body weight. However, obese patients and pubertal adolescents may need more due to insulin resistance.
The basal dose constitutes about 40%-50% of the total daily dose, with the rest as premeal insulin. The mealtime insulin dose should mirror...
Insulin Formulations: Types and Delivery01:27

Insulin Formulations: Types and Delivery

Insulin preparations are categorized by their duration of action into short-acting and long-acting types. Two strategies are used to modify insulin's absorption and pharmacokinetic profile: slowing the absorption post-subcutaneous injection, or altering human insulin's amino acid sequence or protein structure. These changes retain the insulin's ability to bind to the insulin receptor, but alter its behavior in solution or after injection.
Short-acting insulins are divided into rapid-acting...
Drug Accumulation During Multiple Dosing: Intermittent IV Infusions01:24

Drug Accumulation During Multiple Dosing: Intermittent IV Infusions

Intermittent intravenous (IV) infusion is a method of drug administration where medications are delivered over short infusion periods followed by intervals of no drug delivery. This approach helps to prevent sustained high drug concentrations in the bloodstream, reducing the risk of adverse effects associated with prolonged exposure. Unlike continuous infusion, steady-state concentrations may not be achieved during a single dosing cycle but can be reached through repeated...
Acute Kidney Injury V: Interprofessional Care01:20

Acute Kidney Injury V: Interprofessional Care

Acute Kidney Injury (AKI) requires a collaborative healthcare approach to restore renal function and prevent complications. Essential management strategies involve monitoring fluid and electrolyte balance, adjusting medications, initiating dialysis when necessary, and providing nutritional support.Fluid and Electrolyte ManagementFluid Monitoring: Regularly monitoring body weight, central venous pressure, and urine output helps detect fluid imbalances early. Patient intake and output are...
Production of Pharmaceuticals01:30

Production of Pharmaceuticals

Industrial insulin production uses genetically engineered E. coli expressing a proinsulin gene controlled by a tryptophan promoter and containing a methionine linker for later cleavage. The cells also carry ampicillin resistance for selective growth. Seed cultures are stored at −80 °C and production begins by thawing a small amount to inoculate starter cultures, which are progressively scaled to a 50,000-L bioreactor. In the bioreactor, E. coli grow in nutrient-rich media under sterile, tightly...
Hypoglycemia and Glucagon01:15

Hypoglycemia and Glucagon

Without prolonged fasting, healthy individuals maintain blood glucose levels above 3.5 mM due to a well-adapted neuroendocrine counterregulatory system that effectively prevents acute hypoglycemia, a potentially life-threatening condition. The primary clinical scenarios for hypoglycemia encompass diabetes treatment, inappropriate production of endogenous insulin or insulin-like substances by tumors, and the use of glucose-lowering agents in non-diabetic individuals. Notably, hypoglycemia in the...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Norwegian clinical dashboard: updated and expanded versions may lead to further Nordic collaboration.

BMJ leader·2026
Same author

Fully Collective Superradiant Lasing with Vanishing Sensitivity to Cavity Length Vibrations.

Physical review letters·2026
Same author

Why are there waiting lists in the health service, and must we accept them?

Tidsskrift for den Norske laegeforening : tidsskrift for praktisk medicin, ny raekke·2026
Same author

ICM 2025: New Technologies like Artificial Intelligence, Robotics, and Anti-Biofilm.

The Journal of arthroplasty·2025
Same author

Discrete Subdomains Establish Epigenetic Diversity in Subtelomeric Heterochromatin.

bioRxiv : the preprint server for biology·2025
Same author

Parametric modeling of deformable linear objects for robotic outfitting and maintenance of space systems.

Frontiers in robotics and AI·2025

Related Experiment Video

Updated: Jul 11, 2026

Improving IV Insulin Administration in a Community Hospital
12:08

Improving IV Insulin Administration in a Community Hospital

Published on: June 11, 2012

[Insulin infusion for critically ill patients].

Svein Skeie1, Eldar Søreide, John Cooper

  • 1Endokrinologisk seksjon, Medisinsk klinikk, Stavanger universitetssjukehus, Postboks 8100, 4068 Stavanger. sksv@sus.no

Tidsskrift for Den Norske Laegeforening : Tidsskrift for Praktisk Medicin, Ny Raekke
|September 27, 2007
PubMed
Summary

Treating high blood sugar (hyperglycemia) in critically ill patients with insulin infusions improves outcomes. This safe and inexpensive therapy is recommended, especially in intensive care units.

More Related Videos

Use of a Central Venous Line for Fluids, Drugs and Nutrient Administration in a Mouse Model of Critical Illness
09:17

Use of a Central Venous Line for Fluids, Drugs and Nutrient Administration in a Mouse Model of Critical Illness

Published on: May 2, 2017

A Model of Chronic Nutrient Infusion in the Rat
08:18

A Model of Chronic Nutrient Infusion in the Rat

Published on: August 14, 2013

Related Experiment Videos

Last Updated: Jul 11, 2026

Improving IV Insulin Administration in a Community Hospital
12:08

Improving IV Insulin Administration in a Community Hospital

Published on: June 11, 2012

Use of a Central Venous Line for Fluids, Drugs and Nutrient Administration in a Mouse Model of Critical Illness
09:17

Use of a Central Venous Line for Fluids, Drugs and Nutrient Administration in a Mouse Model of Critical Illness

Published on: May 2, 2017

A Model of Chronic Nutrient Infusion in the Rat
08:18

A Model of Chronic Nutrient Infusion in the Rat

Published on: August 14, 2013

Area of Science:

  • Critical Care Medicine
  • Endocrinology

Context:

  • Stress, acute illness, and surgery elevate blood sugar levels.
  • Hyperglycemia in critically ill patients correlates with increased mortality, regardless of diabetes status.
  • Numerous randomized trials have investigated insulin infusion therapy for critically ill patients.

Purpose:

  • To review the evidence and clinical experience regarding insulin therapy for hyperglycemia in critically ill patients.
  • To establish treatment targets and safety considerations for insulin infusions.

Summary:

  • Insulin therapy is effective in normalizing blood glucose levels, particularly in myocardial infarction and intensive care unit patients.
  • Insulin infusion is recommended when plasma glucose exceeds 8 mmol/L, targeting 4-6 mmol/L.
  • While serious hypoglycemia risk is low, systematic blood glucose monitoring is crucial.

Impact:

  • Insulin therapy offers an inexpensive and safe method to enhance patient outcomes in critical care settings.
  • Increased utilization of insulin infusions for hyperglycemia is advised in intensive care and coronary care units.