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Related Experiment Videos

Addressing a vascular endothelium array with blood components using underlying microfluidic channels.

Luiza I Genes1, Nicole V Tolan, Matthew K Hulvey

  • 1Department of Chemistry, Michigan State University, East Lansing, MI 48824, USA.

Lab on a Chip
|September 27, 2007
PubMed
Summary
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This study introduces an in vitro model using endothelial cells and microfluidics to mimic blood circulation. This system allows for monitoring cell communication, aiding drug discovery.

Area of Science:

  • Biomedical Engineering
  • Cell Biology
  • Pharmacology

Background:

  • Understanding cellular communication is crucial for drug discovery.
  • Existing in vitro models often fail to replicate the complexity of in vivo circulation.

Purpose of the Study:

  • To develop an advanced in vitro model for studying cell-cell interactions.
  • To enhance the drug discovery process through improved cellular communication monitoring.

Main Methods:

  • Utilizing an array of endothelial cells.
  • Employing a microfluidic network with red blood cells.
  • Simulating in vivo circulation conditions.

Main Results:

  • Demonstrated a functional in vitro model of blood circulation.

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  • Successfully monitored cellular communication between different cell types.
  • Validated the model's utility in the drug discovery context.

    • Conclusions:

    • The developed microfluidic system serves as a valuable in vitro model for in vivo circulation.
    • This model facilitates the study of cellular communication, offering a novel approach for drug discovery.