Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

3D-Printed Metamaterial-Based Soft Sensors: Materials, Design, and Fabrications.

Small (Weinheim an der Bergstrasse, Germany)·2026
Same author

Evaluating Curvature-Induced Variation in Deep Learning-Based Beamforming for Flexible Transducers in Ultrasound-Guided Radiation Therapy.

Bioengineering (Basel, Switzerland)·2026
Same author

Correlation between changes in substructure diffusion tensor imaging and neurocognitive outcomes for pediatric brain tumor survivors.

Neuro-oncology advances·2026
Same author

Ensemble-Based Source Attribution of Fine Particulate Matter over South Korea during the ASIA-AQ/SIJAQ Campaign.

Environmental science & technology·2026
Same author

Prospective operational feasibility, safety, and workflow of magnetic resonance-guided tracking technology for interstitial gynecologic brachytherapy.

Brachytherapy·2026
Same author

Measuring Network Sizes in the Context of Respondent Driven Sampling: Evidence from Two Independent Surveys.

Survey research methods·2026

Related Experiment Video

Updated: Jul 11, 2026

Evaluation of Cardiac Contractility Modulation Therapy in 2D Human Stem Cell-Derived Cardiomyocytes
08:47

Evaluation of Cardiac Contractility Modulation Therapy in 2D Human Stem Cell-Derived Cardiomyocytes

Published on: December 16, 2022

Micro pumping with cardiomyocyte-polymer hybrid.

Jungyul Park1, Il Chaek Kim, Jeongeun Baek

  • 1Biomedical Engineering, Johns Hopkins University, 207 Clark Hall, 3400 N. Charles St., Baltimore, MD 21218, USA. sortpark@gmail.com

Lab on a Chip
|September 27, 2007
PubMed
Summary

This study introduces a novel cell-based micropump. Self-beating heart cells power a microfluidic device, creating flow without external energy sources.

More Related Videos

Generation of Aligned Functional Myocardial Tissue Through Microcontact Printing
11:09

Generation of Aligned Functional Myocardial Tissue Through Microcontact Printing

Published on: March 19, 2013

Sarcomere Shortening of Pluripotent Stem Cell-Derived Cardiomyocytes using Fluorescent-Tagged Sarcomere Proteins.
08:37

Sarcomere Shortening of Pluripotent Stem Cell-Derived Cardiomyocytes using Fluorescent-Tagged Sarcomere Proteins.

Published on: March 3, 2021

Related Experiment Videos

Last Updated: Jul 11, 2026

Evaluation of Cardiac Contractility Modulation Therapy in 2D Human Stem Cell-Derived Cardiomyocytes
08:47

Evaluation of Cardiac Contractility Modulation Therapy in 2D Human Stem Cell-Derived Cardiomyocytes

Published on: December 16, 2022

Generation of Aligned Functional Myocardial Tissue Through Microcontact Printing
11:09

Generation of Aligned Functional Myocardial Tissue Through Microcontact Printing

Published on: March 19, 2013

Sarcomere Shortening of Pluripotent Stem Cell-Derived Cardiomyocytes using Fluorescent-Tagged Sarcomere Proteins.
08:37

Sarcomere Shortening of Pluripotent Stem Cell-Derived Cardiomyocytes using Fluorescent-Tagged Sarcomere Proteins.

Published on: March 3, 2021

Area of Science:

  • Biomedical Engineering
  • Microfluidics
  • Cellular Engineering

Background:

  • Microfluidic devices often require external power sources, which can be complex or harmful to biological samples.
  • Developing self-powered microfluidic systems is crucial for advanced lab-on-a-chip applications.

Purpose of the Study:

  • To develop a novel hybrid micropump powered by biological cells.
  • To demonstrate a cell-microdevice hybrid lab-on-a-chip that operates without external power.

Main Methods:

  • Fabrication of a hybrid micropump using a dome-shaped cell-polymer membrane composite.
  • Culturing self-beating cardiomyocytes on the membrane to actuate a microchamber.
  • Utilizing diffuser/nozzle geometry for flow direction control in a microchannel.
  • Monitoring fluid motion via polystyrene bead tracking.

Main Results:

  • Achieved a net flow rate of 0.226 nanoliters per minute.
  • Demonstrated robust and long-term activity of cardiomyocytes due to a noninvasive fabrication process.
  • Successfully created a self-actuated microfluidic system.

Conclusions:

  • The developed cell-actuated micropump offers a unique, power-free solution for microfluidic applications.
  • This technology minimizes risks of electrical or heat shock to sensitive analytes.
  • The hybrid approach advances the development of self-contained lab-on-a-chip systems.