Related Experiment Video

Updated: Jul 11, 2026

Platelet Adhesion and Aggregation Under Flow using Microfluidic Flow Cells
10:10

Platelet Adhesion and Aggregation Under Flow using Microfluidic Flow Cells

Published on: October 27, 2009

Collagen receptors as potential targets for novel anti-platelet agents

Kenneth J Clemetson1, Jeannine M Clemetson

  • 1Theodor Kocher Institute, University of Berne, Freiestrasse 1, CH-3012, Berne, Switzerland. clemetson@tki.unibe.ch

Current Pharmaceutical Design
|September 28, 2007
PubMed

Insights

Targeting collagen receptors on platelets may offer new ways to inhibit thrombosis and atherosclerosis. This approach aims to reduce bleeding complications associated with current platelet inhibitors.

Area of Science:

  • Cardiovascular Research
  • Hematology
  • Pharmacology

Background:

  • Platelets play a key role in atherosclerosis and thrombosis.
  • Current platelet inhibitors can cause bleeding complications by affecting normal hemostasis.
  • There is a need for novel inhibitors with improved safety profiles.

Purpose of the Study:

  • To review potential therapeutic targets for platelet inhibition.
  • To assess collagen receptors as alternative targets for reducing thrombosis and atherosclerosis.
  • To evaluate strategies for minimizing bleeding risks associated with antiplatelet therapies.

Main Methods:

  • Review of scientific literature on platelet function and inhibitors.
  • Analysis of data from various thrombosis models and experimental approaches.
  • Assessment of three key collagen receptors: alpha2beta1 integrin, GPVI, and GPIb-V-IX.

Main Results:

  • Collagen receptors represent promising targets for early-stage platelet activation inhibition.
  • Alpha2beta1 integrin mediates platelet adhesion to collagen.
  • GPVI is a major signaling receptor for collagen, and GPIb-V-IX acts indirectly via von Willebrand factor.

Conclusions:

  • Targeting collagen receptors could lead to more effective antiplatelet therapies.
  • Further investigation into alpha2beta1 integrin, GPVI, and GPIb-V-IX is warranted.
  • These receptors offer potential for developing inhibitors that reduce thrombosis and atherosclerosis with fewer bleeding complications.

More Related Videos

Turbidimetry on Human Washed Platelets: The Effect of the Pannexin1-inhibitor Brilliant Blue FCF on Collagen-induced Aggregation09:13

Turbidimetry on Human Washed Platelets: The Effect of the Pannexin1-inhibitor Brilliant Blue FCF on Collagen-induced Aggregation

Published on: April 6, 2017

Reproducibility and Harmonization in Research Using Biological Standards: The Example of Platelet Agonist Collagen-Related Peptide04:50

Reproducibility and Harmonization in Research Using Biological Standards: The Example of Platelet Agonist Collagen-Related Peptide

Published on: August 4, 2023

Related Concept Videos

Antiplatelet Drugs: Prostaglandin Synthesis, P2Y12 and Glycoprotein IIb/IIIa Inhibitors01:20

Antiplatelet Drugs: Prostaglandin Synthesis, P2Y12 and Glycoprotein IIb/IIIa Inhibitors

Antiplatelet drugs emerge as frontline defenders against the insidious threat of thromboembolic diseases, where abnormal clots obstruct vital blood vessels. These drugs stand as bulwarks, inhibiting platelet aggregation and clot formation, thereby mitigating the risk of life-threatening conditions like myocardial infarction, coronary artery disease, and thrombotic strokes.
Prostaglandin synthesis inhibitors, exemplified by the widely known aspirin, wield their power by irreversibly acetylating...
Formation of the Platelet Plug01:22

Formation of the Platelet Plug

The platelet phase, the second stage of hemostasis, commences around 15-20 seconds after an injury. It follows and overlaps with the vascular phase, during which blood vessels constrict to minimize blood loss.
As the injured blood vessel contracts, endothelial cells undergo contraction, revealing collagen fibers in the basement membrane and underlying connective tissue. Furthermore, the plasma membrane of endothelial cells becomes adhesive, preparing the site for platelet adhesion. Platelets...
Transducer Mechanism: Enzyme-Linked Receptors01:27

Transducer Mechanism: Enzyme-Linked Receptors

Enzyme-linked receptors are cell-surface receptors acting as an enzyme or associating with an enzyme intracellularly. They make excellent drug targets. Drugs can bind to the extracellular ligand-binding domain or directly affect their enzymatic domain and alter their activity.
Major types that are helpful drug targets include:
Structural Protein Function01:56

Structural Protein Function

Structural proteins are a category of proteins responsible for functions ranging from cell shape and movement to providing support to major structures such as bones, cartilage, hair, and muscles. This group includes proteins such as collagen, actin, myosin, and keratin.
Collagen, the most abundant protein in mammals, is found throughout the body. In connective tissue, such as skin, ligaments, and tendons, it provides tensile strength and elasticity.  In bones and teeth, it mineralizes to form...
Fibril-associated Collagen01:11

Fibril-associated Collagen

Fibril-associated collagens are a type of collagens present in the extracellular matrix with interrupted triple helices or FACIT (Fibril-associated collagens interrupted triple-helices). FACIT help connect and attach the collagen fibrils with each other as well as with other proteins of the extracellular matrix.
For example, the type II collagen fibrils in cartilage have covalently bound type IX fibril-associated collagens at regular intervals. Other types of fibril-associated collagens are...
Structure and Function of Platelets01:18

Structure and Function of Platelets

The cell fragments known as platelets are disc-shaped, with an average diameter of about 3 μm and a thickness of roughly 1 μm. They play a crucial role in the body's vascular clotting system, which also involves plasma proteins, blood cells, and blood vessel tissues.
Platelets are continually replenished, circulating in the bloodstream for 9-12 days before being removed by phagocytes, primarily in the spleen. A microliter of circulating blood contains between 150,000 and 450,000 platelets, with...