Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Selective glucocorticoid receptor ligands.

Timothy J Cole1, Richard Mollard

  • 1Department of Biochemistry and Molecular Biology, Monash University, Clayton, Victoria, Australia. tim.cole@med.monash.edu.au

Medicinal Chemistry (Shariqah (United Arab Emirates))
|September 28, 2007
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Role of Mineralocorticoid Receptors in Cardiovascular Disease.

Hypertension (Dallas, Tex. : 1979)·2026
Same author

Balcinrenone Shows a Unique Regulation of Potassium Excretion in Streptozotocin-induced Diabetes in Male Mice.

Endocrinology·2026
Same author

Temporal mineralocorticoid receptor activation regulates the molecular clock and transcription of cardiovascular disease modulators in myeloid cells.

American journal of physiology. Heart and circulatory physiology·2025
Same author

Disrupted glucocorticoid receptor cell signalling causes a ciliogenesis defect in the fetal mouse renal tubule.

EMBO reports·2025
Same author

Mechanisms of ligand-mediated modulation of mineralocorticoid receptor signaling.

Molecular and cellular endocrinology·2025
Same author

Physiologic and structural characterization of desisobutyryl-ciclesonide, a selective glucocorticoid receptor modulator in newborn rats.

PNAS nexus·2025
Same journal

Evaluation of the Anticancer Potential of Nitro-Benzimidazole Derivatives in Breast Cancer.

Medicinal chemistry (Shariqah (United Arab Emirates))·2026
Same journal

<i>In silico</i> Evaluation of the Antibacterial Potential of the Cyclic Tetrapeptide Tentoxin Derived from <i>Alternaria alternate</i>.

Medicinal chemistry (Shariqah (United Arab Emirates))·2026
Same journal

ZN002: A Novel Natural Product Small Molecule Inhibitor Targets the Coxsackie-Adenovirus Receptor (CAR) to Control Coxsackie B3 Viral Proliferation.

Medicinal chemistry (Shariqah (United Arab Emirates))·2026
Same journal

<i>In silico</i> and <i>in vitro</i> Analysis of Secondary Metabolites of <i>Pleurotus djamor</i> Against Targets of <i>Haemonchus contortus</i>.

Medicinal chemistry (Shariqah (United Arab Emirates))·2026
Same journal

Indole-2-carboxylic Acid Hydrazones and Hydroxamic Acid Derivatives: Synthesis and Evaluation of Biological Properties.

Medicinal chemistry (Shariqah (United Arab Emirates))·2026
Same journal

2-Quinolinone Derivatives as Dual Cholinesterase Inhibitors: Experimental and Computational Insights.

Medicinal chemistry (Shariqah (United Arab Emirates))·2026
See all related articles

Glucocorticoids (GRs) are vital steroids, but their long-term use causes side effects. Novel selective GR modulators offer targeted treatments for inflammatory and metabolic diseases with fewer adverse effects.

Area of Science:

  • Endocrinology and Molecular Biology
  • Steroid Hormone Action
  • Drug Discovery

Background:

  • Glucocorticoids (GRs) are essential four-ring steroid compounds regulating diverse physiological processes, including immune function and stress response.
  • Synthetic glucocorticoids like dexamethasone are widely used for inflammatory diseases but cause significant side effects with prolonged use.
  • Understanding GR cell signaling is crucial for developing safer therapeutic agents.

Purpose of the Study:

  • To explore the development and potential of novel selective glucocorticoid receptor ligands.
  • To investigate compounds that modulate GR transcriptional activity for targeted disease treatment.
  • To identify therapeutic strategies that minimize the side effects associated with traditional glucocorticoid therapy.

Main Methods:

Related Experiment Videos

  • Review of cell signaling mechanisms of Glucocorticoid Receptor (GR) action.
  • Analysis of novel selective GR ligands, including methane sulphonamides, A-348441, benzopyranoquinolines, and arylpyrazoles.
  • Examination of GR antagonist and selective GR modulator properties in cell-based and animal models.

Main Results:

  • Novel selective GR ligands demonstrate potential for more efficient disease treatment with reduced side effects.
  • Specific compounds like methane sulphonamides and A-348441 show promise as GR antagonists.
  • Other ligand classes, such as benzopyranoquinolines and arylpyrazoles, selectively modulate GR transcriptional activity.

Conclusions:

  • Selective GR modulators represent a promising therapeutic approach for inflammatory and metabolic diseases like type-2 diabetes.
  • Targeted modulation of GR transcriptional regulation can lead to improved treatment efficacy and safety.
  • Further research into selective GR ligands could revolutionize the management of various chronic conditions.