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Related Experiment Video

Updated: Jul 11, 2026

Assessment of Vascular Regeneration in the CNS Using the Mouse Retina
07:32

Assessment of Vascular Regeneration in the CNS Using the Mouse Retina

Published on: June 23, 2014

Transthyretin enhances nerve regeneration.

Carolina E Fleming1, Maria J Saraiva, Mónica M Sousa

  • 1Instituto de Biologia Molecular e Celular--IBMC, Molecular Neurobiology Group, Porto, Portugal.

Journal of Neurochemistry
|September 28, 2007
PubMed
Summary

Transthyretin (TTR) plays a crucial role in nerve physiology and regeneration. Studies show TTR enhances nerve repair and neurite outgrowth, explaining its role in peripheral nerve health.

Related Experiment Videos

Last Updated: Jul 11, 2026

Assessment of Vascular Regeneration in the CNS Using the Mouse Retina
07:32

Assessment of Vascular Regeneration in the CNS Using the Mouse Retina

Published on: June 23, 2014

Area of Science:

  • Neuroscience
  • Molecular Biology
  • Genetics

Background:

  • Mutations in transthyretin (TTR) are linked to familial amyloid polyneuropathy, a condition involving TTR deposition in the peripheral nervous system (PNS).
  • The specific physiological role of TTR in nerve function and its preferential accumulation in the PNS when mutated remain unclear.

Purpose of the Study:

  • To investigate the role of transthyretin (TTR) in peripheral nerve physiology and regeneration.
  • To understand why mutated TTR preferentially deposits in the PNS.

Main Methods:

  • Comparison of sensorimotor performance between wild-type and TTR knockout (KO) mice.
  • Assessment of nerve regeneration after nerve crush injury in both mouse strains.
  • In vitro assays to evaluate neurite outgrowth in the absence of TTR.

Main Results:

  • TTR knockout mice exhibited impaired sensorimotor performance and delayed functional recovery after nerve injury.
  • TTR deficiency led to a reduced number of myelinated and unmyelinated nerve fibers during regeneration.
  • In vitro studies showed decreased neurite outgrowth and extension in the absence of TTR.
  • Transgenic expression of human TTR in TTR KO mice rescued the observed nerve regeneration deficits.

Conclusions:

  • Transthyretin (TTR) is integral to nerve physiology and significantly enhances nerve regeneration.
  • The findings suggest that TTR's role in nerve biology and repair may explain its preferential deposition in the PNS of familial amyloid polyneuropathy patients.