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Management of systemic hypertension in children and adolescents: an update
Mark C Johnson1, Cortney J Schneider, Anne M Beck
1Pediatric Cardiology, Washington University School of Medicine, St. Louis Children's Hospital, Campus Box 8116-NWT, St. Louis, MO 63110, USA. Johnson_m@kids.wustl.edu
Insights
Pediatric hypertension management is crucial for preventing future cardiovascular disease. Early identification and treatment, including lifestyle changes and medication, can decrease long-term risks in children.
Area of Science:
- Pediatric Nephrology
- Cardiology
- Public Health
Background:
- Hypertension in children is an emerging health concern with potential long-term cardiovascular implications.
- Establishing a definitive link between childhood hypertension and adult cardiovascular disease risk is essential.
- Addressing associated risk factors like obesity and dyslipidemia is critical for comprehensive management.
Purpose of the Study:
- To outline current strategies for the identification and management of hypertension in pediatric populations.
- To emphasize the importance of early intervention in reducing future cardiovascular morbidity and mortality.
- To provide guidance on pharmacologic and non-pharmacologic treatment approaches based on hypertension severity and specific conditions.
Main Methods:
- Review of current guidelines and evidence for pediatric hypertension diagnosis and treatment.
- Discussion of lifestyle modifications, pharmacotherapy indications, and interventional procedures.
- Consideration of specific pediatric hypertension etiologies, including coarctation of the aorta and renal artery stenosis.
Main Results:
- Lifestyle modifications are recommended for all pediatric hypertension patients, particularly those with blood pressure between the 95th and 99th percentiles.
- Pharmacologic therapy is indicated for severe hypertension ( > 99th percentile), secondary hypertension, or when lifestyle changes fail.
- Interventional treatments like angioplasty or surgery are options for specific conditions such as renal artery stenosis and coarctation of the aorta.
Conclusions:
- Consistent identification and treatment of pediatric hypertension are vital for long-term cardiovascular health.
- Tailored treatment strategies, including lifestyle changes, medication, and interventions, are necessary for optimal outcomes.
- Further long-term studies are needed to solidify the link between childhood hypertension treatment and reduced adult cardiovascular disease.
Abstract:
Identification and treatment of hypertension should be an important focus of physicians caring for children. Ultimately, a link between hypertension in children and the risk of cardiovascular disease will be established. Further long-term studies are likely to show that morbidity and mortality will be decreased by the institution of treatment of hypertension in children. Additional risk factors such as obesity and lipid disorders should be sought and targeted for treatment as well. Lifestyle modifications are advised for all patients and can be tried solely for those with blood pressures between the 95th and 99th percentiles. Drug therapy is indicated in children with blood pressures greater than the 99th percentile, secondary hypertension, coexisting diabetes, left ventricular hypertrophy, or those who fail a trial of nonpharmacologic treatment. Children with white coat hypertension should not be treated with drugs. Children with renal artery stenosis and drug-refractory hypertension should be considered for percutaneous angioplasty or surgery depending on the anatomy of the lesion and operator experience. Children requiring multiple drug classes for control of blood pressure and older adolescents on one drug with renal artery lesions amenable to a percutaneous procedure may elect intervention in an attempt to reduce or eliminate drug therapy. Infants and children with hypertension due to native coarctation of the aorta should undergo surgical repair. Older children and adolescents with native coarctation should have surgical repair or percutaneous angioplasty/stenting. Hypertension secondary to recurrent coarctation is usually treated with a percutaneous intervention.
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