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Updated: Jul 11, 2026

Surgical Models of Gastroesophageal Reflux with Mice
Published on: August 25, 2015
Treatment options in pediatric GERD
Neelesh A Tipnis1, Colin D Rudolph
1Neelesh A. Tipnis, MD Department of Pediatrics, Medical College of Wisconsin, 8701 Watertown Plank Road, Milwaukee, WI 53226, USA. ntipnis@mcw.edu
Insights
Gastroesophageal reflux disease (GERD) in children requires careful evaluation and treatment. Acid-suppression therapy is common for GERD, but its goals and risks must be weighed before use.
Area of Science:
- Pediatric Gastroenterology
- Infant Health
- Digestive Disorders
Background:
- Gastroesophageal reflux (GER) is a normal physiological process in infants and children.
- When GER causes symptoms or complications, it is termed gastroesophageal reflux disease (GERD).
- GERD necessitates specific diagnostic approaches and therapeutic interventions.
Purpose of the Study:
- To outline the evaluation and management of GERD in pediatric populations.
- To emphasize the importance of judicious pharmacologic treatment for GERD.
- To discuss the considerations surrounding acid-suppression therapy and surgical options.
Main Methods:
- Review of current clinical practices and literature regarding GERD in children.
- Analysis of the role of acid-suppression therapy in managing GERD symptoms.
- Evaluation of the indications and limitations of surgical interventions for GERD.
Main Results:
- Acid-suppression therapy is the primary pharmacological approach for GERD.
- Careful consideration of treatment objectives and potential adverse effects of acid suppression is crucial.
- Surgical treatment for GERD in children has a limited scope.
Conclusions:
- Effective management of pediatric GERD involves targeted evaluation and appropriate treatment strategies.
- Pharmacological treatment, particularly acid suppression, should be used judiciously, balancing benefits against risks.
- The role of surgery in GERD management is currently restricted.
Abstract:
Gastroesophageal reflux (GER) is a common physiologic phenomenon in infants and children. GER that results in symptoms or complications--hence the evolution to GER disease (GERD)--warrants targeted evaluation and appropriate treatment. Judicious use of acid-suppression therapy remains the mainstay of pharmacologic treatment of GERD. However, recognition of treatment goals and potentials risks of acid suppression must be considered prior to initiation of therapy. The role of surgical intervention for GERD remains limited.
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