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Updated: Jul 11, 2026
An Orthotopic Endometrial Cancer Model with Retroperitoneal Lymphadenopathy Made From In Vivo Propagated and Cultured VX2 Cells
Published on: September 12, 2019
Surgical treatment for neuroendocrine carcinoma of the uterine cervix
T Kasamatsu1, Y Sasajima, T Onda
1Division of Gynecology, National Cancer Center Hospital, Chuo-ku, Tokyo, Japan. Takasama@ncc.go.jp
Objective:
To identify the best operative approach for neuroendocrine cervical carcinoma (NECC).
Methods:
The records of surgically treated patients with stages IB to IIB NECC were reviewed.
Results:
Of 10 patients who met the study criteria for NECC and underwent radical hysterectomy, 4 had pT1bN0, 4 had pT1bN1, 1 had pT2aN0, and 1 had pT2bN1 disease. Those with pT1bN1 or pT2bN1 disease received postoperative adjuvant radiotherapy and/or chemotherapy, and recurrence occurred in 7 patients (70%). Among these 7 patients, 5 (71%) had a primary NECC tumor with deep stromal invasion and 5 (71%) had extrauterine disease (parametrium and/or lymph node). The recurrences in 6 patients (86%) were located outside the pelvis (lung, liver, or brain). Stromal invasion was 6 mm or less in the 3 patients who did not experience disease recurrence.
Conclusions:
Pelvic control by radical hysterectomy may not be beneficial for patients with NECC except for those with an early invasive lesion.