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Related Experiment Video

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Large-scale Three-dimensional Imaging of Cellular Organization in the Mouse Neocortex

Large-scale Three-dimensional Imaging of Cellular Organization in the Mouse Neocortex

Published on: September 5, 2018

Layer V neurons in mouse cortex projecting to different targets have distinct physiological properties.

Alexis M Hattox¹, Sacha B Nelson

¹Department of Biology, MS 008, Brandeis University, Waltham, MA 02454, USA.

Journal of Neurophysiology

|September 28, 2007

Summary

Layer V pyramidal neurons projecting to different brain areas form distinct cell groups with unique physiological properties. This research clarifies the relationship between neuron anatomy, physiology, and their specific projection targets in the cortex.

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Last Updated: Jul 11, 2026

Large-scale Three-dimensional Imaging of Cellular Organization in the Mouse Neocortex

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Published on: September 5, 2018

Laser-scanning Photostimulation of Optogenetically Targeted Forebrain Circuits

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Targeted Labeling of Neurons in a Specific Functional Micro-domain of the Neocortex by Combining Intrinsic Signal and Two-photon Imaging

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Published on: December 12, 2012

Area of Science:

Neuroscience
Cellular Biology
Systems Neuroscience

Background:

Layer V pyramidal neurons exhibit significant anatomical and physiological diversity.
Previous studies lacked clarity on how neuron properties correlate with specific subcortical projection targets due to unidentified cell populations.

Purpose of the Study:

To investigate if neurons targeting the same subcortical site constitute distinct subpopulations.
To determine if these neuronal subpopulations possess stereotyped physiological characteristics.

Main Methods:

Combined neuroanatomical tract tracing with whole-cell recordings.
Utilized mouse somatosensory cortex for in vivo analysis.

Main Results:

Corticothalamic and corticortrigeminal neurons represent largely non-overlapping subpopulations.
Callosal and corticostriatal neurons show extensive overlap.
Distinct morphological, intrinsic membrane, and firing properties were observed between corticothalamic/corticotrigeminal and callosal/corticostriatal neurons.
Unique afterpotential profiles differentiate neuron classes based on projection targets.

Conclusions:

Neurons projecting to different subcortical targets are distinct populations.
Projection site is a key determinant of neuronal identity within Layer V.
Findings provide a framework for understanding cortical circuit organization based on projection specificity.