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Related Experiment Videos

Colorectal carcinoma: a prospect clinicopathological study.

M T Pheils, J E Barnett, R C Newland

    The Medical Journal of Australia
    |February 28, 1976
    PubMed
    Summary

    This study analyzed 200 colorectal carcinoma cases, finding altered bowel habits and bleeding as common symptoms. Many patients presented with advanced disease, with higher-grade tumors more frequent on the right side of the colon.

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    Low level microsatellite instability may be associated with reduced cancer specific survival in sporadic stage C colorectal carcinoma.

    Gut·2004

    Area of Science:

    • Oncology
    • Gastroenterology
    • Pathology

    Background:

    • Colorectal carcinoma is a significant health concern.
    • Early detection and understanding of disease progression are crucial for effective treatment.
    • Surgical resection remains a primary treatment modality.

    Purpose of the Study:

    • To analyze clinical and pathological findings in 200 colorectal carcinoma cases.
    • To identify common presenting symptoms and stages of disease at diagnosis.
    • To investigate the relationship between tumor characteristics and location.

    Main Methods:

    • Prospective survey of 200 consecutive colorectal carcinoma patients.
    • Computer analysis of clinical and pathological data.
    • Evaluation of diagnostic investigations and surgical resection outcomes.

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    Main Results:

    • Altered bowel habit (51.5%) and bleeding (49.5%) were the most frequent symptoms.
    • 16% presented with anemia, 13.5% with acute obstruction.
    • A majority of patients had advanced-stage disease at resection (26% with incomplete resection).
    • Direct correlation noted between tumor stage, histological grade, and malignancy.
    • Higher incidence of advanced stage, high-grade, and mucinous tumors in the right colon.
    • Early carcinomas frequently originated from benign neoplastic polyps.

    Conclusions:

    • Colorectal carcinoma often presents with advanced disease, highlighting the need for improved early detection strategies.
    • Tumor characteristics vary by location, with right-sided colon cancers showing more aggressive features.
    • The progression from benign polyps to carcinoma is confirmed, emphasizing the importance of polyp surveillance.