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Updated: Jul 11, 2026

Generation of Multivirus-specific T Cells to Prevent/treat Viral Infections after Allogeneic Hematopoietic Stem Cell Transplant

Generation of Multivirus-specific T Cells to Prevent/treat Viral Infections after Allogeneic Hematopoietic Stem Cell Transplant

Published on: May 27, 2011

T-cell therapy after hematopoietic stem cell transplantation.

Alana A Kennedy-Nasser¹, Malcolm K Brenner

¹Center for Cell and Gene Therapy, Baylor College of Medicine, Houston, Texas 77030, USA. aakenned@txccc.org

Current Opinion in Hematology

|September 28, 2007

Summary

Adoptive T-cell immunotherapy after allogeneic hematopoietic stem cell transplantation aims to prevent graft-versus-host disease while enhancing anti-leukemia and anti-viral immunity. Strategies include T-cell selection, expansion, and safety mechanisms like suicide genes.

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Automated Cell Enrichment of Cytomegalovirus-specific T cells for Clinical Applications using the Cytokine-capture System

Automated Cell Enrichment of Cytomegalovirus-specific T cells for Clinical Applications using the Cytokine-capture System

Published on: October 5, 2015

Area of Science:

Immunology
Transplantation Medicine
Oncology

Background:

Allogeneic hematopoietic stem cell transplantation (HSCT) requires T-cell manipulation for therapeutic success.
Key challenges include separating graft-versus-host disease (GvHD) from graft-versus-leukemia (GvL) and restoring immunity to infections.

Purpose of the Study:

To review current strategies for adoptive T-cell immunotherapy post-HSCT.
To highlight advances in T-cell engineering for improved therapeutic outcomes.

Main Methods:

Strategies for eliminating alloreactive T cells.
Expansion of regulatory T cells (Tregs).
Selection and expansion of antigen-specific T cells (tumor and viral).

Main Results:

Development of methods to eliminate alloreactive T cells from grafts.
Successful expansion of naturally occurring regulatory T cells.
Selection and expansion of T cells targeting tumor-associated and viral antigens.
Incorporation of suicide genes enhances safety and applicability of T-cell therapies.

Conclusions:

Current adoptive T-cell immunotherapy strategies offer improved safety and efficacy for HSCT.
Advances in T-cell engineering hold promise for managing GvHD, GvL, and infectious complications.