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Development of a Polymicrobial Colony Biofilm Model to Test Antimicrobials in Cystic Fibrosis
Published on: September 20, 2024
Bacterial biofilms may explain chronicity in osteoradionecrosis of the temporal bone
Robert Nason1, Richard A Chole
1Department of Otolaryngology, Washington University School of Medicine, St. Louis, Missouri 63110, USA.
Objective:
To identify biofilm formation within a case of temporal bone osteoradionecrosis.
Patient:
Single-case patient presenting with temporal bone osteoradionecrosis.
Intervention(S):
Antibiotic therapy and then surgical debridement of the temporal bone.
Main Outcome Measure(S):
Histologic identification of biofilm formation within the affected temporal bone specimen.
Results:
Positive identification of biofilm formation in multiple sections of the temporal bone specimen removed from a patient affected by osteoradionecrosis.
Conclusion:
This is the first evidence that temporal bone osteoradionecrosis involves biofilm formation. Such a pathogenic mechanism may explain the recalcitrance of this disease process and offer new strategies in formulating therapeutic interventions.
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