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Amphotericin B is a broad-spectrum antifungal agent that exploits structural differences between fungal and mammalian cell membranes. Its amphipathic structure—featuring a hydrophobic polyene-lactone ring and a hydrophilic region containing mycosamine and carboxylic acid groups—enables selective binding to ergosterol, a sterol predominantly found in fungal plasma membranes. This selective interaction underlies the drug’s antifungal activity, although weak binding to cholesterol contributes to...
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Updated: Jul 11, 2026

High-resolution Tandem Mass Spectrometry for Studying Chemical Constituents of Gynura bicolor DC
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Published on: February 2, 2024

The dihydro-beta-agarofuran sesquiterpenoids.

Jin-Ming Gao1, Wen-Jun Wu, Ji-Wen Zhang

  • 1College of Sciences, Northwest A & F University, Yangling, Shaanxi 712100, China. jinminggaocn@yahoo.com.cn

Natural Product Reports
|September 28, 2007
PubMed
Summary

Dihydro-Beta-agarofuran sesquiterpenoids, natural products from Celastraceae, exhibit diverse biological activities. This review summarizes 16 years of research on their chemistry and bioactivity, including MDR reversal and antitumor effects.

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A Customizable Approach for the Enzymatic Production and Purification of Diterpenoid Natural Products
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Last Updated: Jul 11, 2026

High-resolution Tandem Mass Spectrometry for Studying Chemical Constituents of Gynura bicolor DC
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Published on: February 2, 2024

A Customizable Approach for the Enzymatic Production and Purification of Diterpenoid Natural Products
07:59

A Customizable Approach for the Enzymatic Production and Purification of Diterpenoid Natural Products

Published on: October 4, 2019

Area of Science:

  • Natural Product Chemistry
  • Organic Chemistry
  • Pharmacology

Background:

  • Dihydro-Beta-agarofuran sesquiterpenoids are a structurally diverse class of natural products.
  • These compounds are based on a tricyclic 5,11-epoxy-5Beta,10alpha-eudesman-4-(14)-ene skeleton.
  • They are primarily isolated from plants in the Celastraceae family.

Purpose of the Study:

  • To review chemical and biological activity research on dihydro-Beta-agarofuran sesquiterpenoids.
  • To cover the period from January 1990 to June 2006.
  • To provide insights into the modes of action for observed biological activities.

Main Methods:

  • Isolation and purification of natural products.
  • Structural elucidation and classification of sesquiterpenoids.
  • Synthesis of dihydro-Beta-agarofuran derivatives.
  • Biological assays to evaluate various activities.

Main Results:

  • 462 new dihydro-Beta-agarofuran sesquiterpenoids of 74 structural types were isolated.
  • Compounds were isolated from 64 Celastraceae species, 3 Hippocrateaceae species, and 1 Lamiaceae species.
  • Identified biological activities include multidrug resistance (MDR) reversal, HIV inhibition, cytotoxicity, antitumor, antifeedant, and insecticidal activities.

Conclusions:

  • Dihydro-Beta-agarofuran sesquiterpenoids represent a rich source of structurally diverse natural products.
  • These compounds demonstrate a wide spectrum of significant biological activities.
  • Further research into their chemical synthesis and modes of action holds therapeutic potential.